{"id":4014,"date":"2023-11-02T13:59:45","date_gmt":"2023-11-02T05:59:45","guid":{"rendered":"https:\/\/transnovo.com\/news\/%e5%a2%9e%e5%8a%a0%e8%be%b9%e7%bc%98%e6%80%a7%e4%be%9b%e8%82%be%e7%9a%84%e5%88%a9%e7%94%a8%e5%8f%8a%e6%94%b9%e5%96%84%e4%be%9b%e8%82%be%e5%8a%9f%e8%83%bd%e7%9a%84%e6%96%b9%e6%a1%88\/"},"modified":"2023-11-14T13:36:46","modified_gmt":"2023-11-14T05:36:46","slug":"%e5%a2%9e%e5%8a%a0%e8%be%b9%e7%bc%98%e6%80%a7%e4%be%9b%e8%82%be%e7%9a%84%e5%88%a9%e7%94%a8%e5%8f%8a%e6%94%b9%e5%96%84%e4%be%9b%e8%82%be%e5%8a%9f%e8%83%bd%e7%9a%84%e6%96%b9%e6%a1%88","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/%e5%a2%9e%e5%8a%a0%e8%be%b9%e7%bc%98%e6%80%a7%e4%be%9b%e8%82%be%e7%9a%84%e5%88%a9%e7%94%a8%e5%8f%8a%e6%94%b9%e5%96%84%e4%be%9b%e8%82%be%e5%8a%9f%e8%83%bd%e7%9a%84%e6%96%b9%e6%a1%88\/","title":{"rendered":"\u589e\u52a0\u201c\u8fb9\u7f18\u6027\u201d\u4f9b\u80be\u7684\u5229\u7528\u53ca\u6539\u5584\u4f9b\u80be\u529f\u80fd\u7684\u65b9\u6848"},"content":{"rendered":"
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\u5668\u5b98\u77ed\u7f3a\u662f\u76ee\u524d\u5668\u5b98\u79fb\u690d\u9886\u57df\u9762\u4e34\u7684\u4e00\u4e2a\u4e3b\u8981\u6311\u6218[1]<\/sup>\u3002\u5c3d\u7ba1\u7f8e\u56fd\u7684\u5668\u5b98\u79fb\u690d\u6570\u91cf\u5728\u9010\u5e74\u589e\u591a\uff0c\u5e76\u57282022\u5e74\u5b9e\u65bd\u4e86\u8d85\u8fc742800\u4f8b\u5668\u5b98\u79fb\u690d\uff08\u7ea625000\u4f8b\u4e3a\u80be\u79fb\u690d\uff09 [2]<\/sup>\uff0c\u4f46\u4ecd\u6709\u8d85\u8fc7100000\u7684\u7b49\u5f85\u79fb\u690d\u60a3\u8005\uff0887% \u7b49\u5f85\u80be\u79fb\u690d\uff09[3]<\/sup>\u3002\u968f\u7740\u4f9b\u4f53\u5668\u5b98\u673a\u68b0\u704c\u6ce8\u6280\u672f\u9010\u6b65\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u65e9\u671f\u88ab\u9057\u5f03\u7684\u8fb9\u7f18\u6027\u4f9b\u4f53\u5668\u5b98\u6b63\u8d8a\u6765\u8d8a\u591a\u5730\u88ab\u4e34\u5e8a\u6240\u63a5\u53d7<\/span><\/strong>\uff0c\u7528\u6765\u5b9e\u65bd\u5668\u5b98\u79fb\u690d\u4ee5\u62ef\u6551\u66f4\u591a\u75c5\u4eba\u7684\u751f\u547d[1] <\/sup>.<\/p>\n

\u8fb9\u7f18\u6027\uff08Marginal\uff09\u4f9b\u4f53\u5668\u5b98\u662f\u6307\u8d28\u91cf\u8f83\u5dee\u7684\u5668\u5b98\uff0c\u5229\u7528\u8fd9\u4e9b\u5668\u5b98\u5b9e\u65bd\u5668\u5b98\u79fb\u690d\u540e\uff0c\u5668\u5b98\u5b58\u6d3b\u7387\u548c\u53d7\u8005\u5b58\u6d3b\u7387\u90fd\u660e\u663e\u964d\u4f4e[1, 4, 5] <\/sup>\u3002\u4f46\u91c7\u7528\u9002\u5f53\u7684\u63aa\u65bd\u53ef\u4f7f\u5f88\u591a\u8fb9\u7f18\u6027\u4f9b\u4f53\u5668\u5b98\u88ab\u5229\u7528\uff0c\u4e14\u79fb\u690d\u540e\u7684\u7ed3\u679c\u5728\u4e34\u5e8a\u4e0a\u662f\u53ef\u63a5\u53d7\u7684[1] <\/sup>\u00a0\u3002\u76ee\u524d\uff0c\u589e\u52a0\u8fb9\u7f18\u6027\u4f9b\u80be\u5229\u7528\u5e76\u6539\u5584\u79fb\u690d\u540e\u4e34\u5e8a\u7ed3\u679c\u7684\u4e3b\u8981\u63aa\u65bd\u65b9\u6848\u4e3a\uff1a1\uff09\u7ed3\u5408\u4f9b\u4f53\u75c5\u53f2\u3001\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u53ca\u5668\u5b98\u8d28\u91cf\u8bc4\u5206\uff08\u5982ECD\u3001DCD\u3001KDPI\u7b49\uff09\uff0c\u5bf9\u4f9b\u4f53\u80be\u810f\u8fdb\u884c\u8d28\u91cf\u8bc4\u4f30\uff0c \u5e76\u5bf9\u4f9b\u53d7\u4f53\u5b9e\u65bd\u6700\u4f73\u5339\u914d\uff1b2\uff09\u9009\u62e9\u6700\u4f73\u624b\u672f\u65b9\u6848\uff0c\u4ee5\u51cf\u5c11\u5668\u5b98\u7684\u70ed\u7f3a\u8840\u65f6\u95f4\uff08WIT\uff09\u548c\u51b7\u7f3a\u8840\u65f6\u95f4\uff08CIT\uff09\uff0c\u5728\u4f9b\u4f53\u624b\u672f\u4e2d\u5bf9\u5668\u5b98\u8fdb\u884c\u76f4\u89c2\u8bc4\u4f30\uff0c\u4ee5\u53ca\u80be\u6d3b\u68c0\u5bf9\u8fb9\u7f18\u6027\u4f9b\u80be\u7684\u8fdb\u4e00\u6b65\u8bc4\u4f30\uff1b3\uff09\u4f9b\u4f53\u624b\u672f\u83b7\u53d6\u80be\u810f\u540e\u7684\u673a\u68b0\u704c\u6ce8[6] <\/sup>.\u672c\u6587\u4e3b\u8981\u5bf9\u8fb9\u7f18\u6027\u4f9b\u80be\u7684\u4f9b\u4f53\u672f\u524d\u3001\u672f\u4e2d\u8bc4\u4f30\u4ee5\u53ca\u4f9b\u80be\u83b7\u53d6\u540e\u7684\u4f53\u5916\u673a\u68b0\u704c\u6ce8\u8fdb\u884c\u9610\u8ff0<\/strong><\/span>.<\/span><\/strong><\/p>\n

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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u4f9b\u4f53\u624b\u672f\u524d\u80be\u810f\u7684\u8bc4\u4f30<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f9b\u4f53\u80be\u810f\u7684\u8d28\u91cf\u51b3\u5b9a\u4e86\u79fb\u690d\u540e\u7684\u4e34\u5e8a\u7ed3\u679c\u3002\u4f9b\u4f53\u75c5\u53f2\u3001\u80be\u529f\u80fd\u68c0\u67e5\u3001\u5668\u5b98\u8d28\u91cf\u8bc4\u5206\u53ef\u5e2e\u52a9\u5bf9\u80be\u810f\u8d28\u91cf\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n

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1.1\u6269\u5927\u6807\u51c6\u4f9b\u4f53<\/strong><\/p>\n

\uff08Expanded-criteria-donor\uff0cECD\uff09<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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ECD\u4e8e2002\u5e74\u83b7\u7f8e\u56fd\u5668\u5b98\u83b7\u53d6\u79fb\u690d\u7f51\u7edc\uff08Organ Procurement and Transplantation Network, OPTN\uff09\u8bba\u8bc1\u5ba1\u6279\uff0c\u5c06\u5176\u4f5c\u4e3a\u8bc4\u4f30\u4f9b\u4f53\u80be\u810f\u8d28\u91cf\u7684\u4e00\u4e2a\u6307\u6807\u3002ECD\u4e3b\u8981\u662f\u6307\u6b7b\u4ea1\u4f9b\u4f53\u5e74\u9f84 >60\u5c81\u6216\u5e74\u9f84\u572850-59\u5c81\u95f4\u5177\u5907\u4e0b\u8ff0\u4e09\u4e2a\u6307\u6807\u4e2d\u7684\u4e24\u4e2a\uff1a1\uff09\u9ad8\u8840\u538b\u75c5\uff1b2\uff09\u8840\u808c\u9150\uff08Cr\uff09>1.5 mg\/dL\uff1b3\uff09\u6b7b\u56e0\u4e3a\u8111\u8840\u7ba1\u610f\u5916[7]<\/sup> \u3002\u76f8\u5bf9\u4e8e\u6807\u51c6\u4f9b\u4f53\u800c\u8a00\uff0cECD\u80be\u810f\u79fb\u690d\u540e\u80be\u810f\u529f\u80fd\u6062\u590d\u5ef6\u8fdf\uff08DGF\uff09\u7684\u6982\u7387\u660e\u663e\u589e\u591a[7, 8]<\/sup>\u3002\u65e9\u671f\u4e34\u5e8a\u5b9e\u8df5\u663e\u793a\uff0cECD\u80be\u810f\u79fb\u690d\u540e\u79fb\u690d\u80be\u7684\u9884\u671f\u5bff\u547d\u7ea6\u4e3a5.1\u5e74\uff0c\u800c\u6807\u51c6\u4f9b\u80be\u7684\u9884\u671f\u5bff\u547d\u7ea6\u4e3a10\u5e74[7]<\/sup>\uff0c\u6545\u5728\u8fdb\u884c\u4f9b\u53d7\u4f53\u5339\u914d\u65f6\uff0c\u5e94\u5c3d\u91cf\u8003\u8651\u4e0d\u8981\u628aECD\u80be\u810f\u7528\u4e8e\u8f83\u5e74\u8f7b\u7684\u53d7\u4f53\u3002<\/p>\n

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1.2\u80be\u810f\u4f9b\u4f53\u6982\u51b5\u6307\u6570 \uff08KDPI\uff09<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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KDPI \u662f\u8bc4\u4f30\u6b7b\u4ea1\u4f9b\u4f53\u80be\u810f\u8d28\u91cf\u7684\u4e00\u4e2a\u8bc4\u4f30\u7cfb\u7edf\u3002KDPI\u901a\u8fc7\u4f9b\u4f53\u768410\u4e2a\u53c2\u6570\u8ba1\u7b97\u540e\u5f97\u5230\u4e00\u4e2a\u767e\u5206\u6570\u503c\uff08%\uff09\uff0c\u7528\u6765\u9884\u4f30\u79fb\u690d\u540e\u4f9b\u80be\u7684\u5b58\u6d3b\u65f6\u95f4[9]<\/sup> \u3002\u7f8e\u56fd\u4ece2014\u5e74\u5e74\u5e95\u5f00\u59cb\u4f7f\u7528KDPI\u8bc4\u4f30\u7cfb\u7edf\u5b9e\u65bd\u4f9b\u4f53\u80be\u810f\u7684\u5206\u914d\uff0c\u79fb\u690d\u4e2d\u5fc3\u53ef\u6839\u636e\u4e0d\u540c\u53d7\u4f53\u7684\u5177\u4f53\u60c5\u51b5\u9009\u62e9\u4e0d\u540cKDPI\u7684\u80be\u810f\uff0c\u4e5f\u53ef\u6839\u636eKDPI\u503c\u6765\u51b3\u5b9a\u662f\u5426\u63a5\u53d7\u6b64\u4f9b\u80be\u7528\u4e8e\u79fb\u690d [4, 10]<\/sup> \u3002KDPI\u503c\u53ef\u5927\u4f53\u9884\u4f30\u79fb\u690d\u80be\u810f\u7684\u5de5\u4f5c\u5e74\u9650 \uff08\u56fe1\uff09\uff0c\u8f83\u9ad8KDPI\u4f9b\u80be\u7684\u9884\u671f\u5bff\u547d\u76f8\u5bf9\u8f83\u77ed\uff0c\u6545\u5728\u8fdb\u884c\u4f9b\u53d7\u4f53\u5339\u914d\u65f6\uff0c\u5e94\u5c3d\u91cf\u8003\u8651\u4e0d\u8981\u628a\u592a\u9ad8KDPI\u7684\u4f9b\u80be\uff08\u5982KDPI >85%\uff09\u7528\u4e8e\u8f83\u5e74\u8f7b\u7684\u53d7\u4f53\uff0c\u7279\u522b\u662f\u513f\u7ae5\u53d7\u4f53\u3002<\/p>\n

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\u56fe1. KDPI\u9884\u4f30\u80be\u79fb\u690d\u540e\u80be\u810f\u7684\u5b58\u6d3b\u65f6\u95f4 <\/span>[9]<\/sup><\/p>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u4f9b\u4f53\u624b\u672f\u65b9\u5f0f\u7684\u9009\u62e9<\/strong>\u548c\u5668\u5b98\u8d28\u91cf\u7684\u8bc4\u4f30<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.1\u4e0d\u540c\u4f9b\u4f53\u83b7\u53d6\u624b\u672f\u65b9\u5f0f\u7684\u9009\u62e9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9009\u62e9\u6700\u4f73\u7684\u624b\u672f\u65b9\u6848\u53ef\u4ee5\u7f29\u77edWIT\u548cCIT\uff0c\u589e\u52a0\u5fc3\u6b7b\u4ea1\u4f9b\u4f53\uff08DCD\uff09\u4f9b\u80be\u7684\u5229\u7528\u7387\u53ca\u6539\u5584\u79fb\u690d\u540e\u7684\u4e34\u5e8a\u7ed3\u679c\u3002\u8111\u6b7b\u4ea1\u4f9b\u4f53\uff08DBD\uff09\u4e00\u822c\u91c7\u7528\u5e38\u89c4\u7684\u4f9b\u4f53\u624b\u672f\u65b9\u5f0f\uff0c\u5bf9DCD\u4f9b\u4f53\u76ee\u524d\u4e3b\u8981\u91c7\u7528\u5feb\u901f\u963b\u65ad\u5e76\u704c\u6ce8\u6cd5[11]<\/sup>\u3002\u8fd1\u5e74\u6765\uff0c\u4f53\u5185\u5e38\u6e29\u5c40\u90e8\u704c\u6ce8\uff08Normothermic reginal perfusion, NRP \uff09[12] <\/sup>\u4e5f\u8d8a\u6765\u8d8a\u591a\u5730\u5e94\u7528\u4e8e\u4e34\u5e8a\uff08\u56fe2\uff09\u3002\u4f7f\u7528NRP\u540e\u80fd\u660e\u663e\u5730\u589e\u52a0DCD\u5668\u5b98\u7684\u5229\u7528\u7387\uff0c\u5e76\u6539\u5584\u79fb\u690d\u540e\u7684\u7ed3\u679c\uff08\u56fe3\uff09[13, 14]<\/sup>.<\/p>\n

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\u56fe2. \u4f53\u5185\u533a\u57df\u6027\u5e38\u6e29\u704c\u6ce8 \uff08In Situ \u2013 NRP\uff09<\/p>\n

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\u56fe3. NRP\u5bf9DCD\u4f9b\u4f53\u80be\u810f\u7684\u4f5c\u7528<\/p>\n

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2.2\u80be\u810f\u6d3b\u68c0 \uff08Biopsy\uff09<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u5916\u79d1\u533b\u751f\u5bf9\u80be\u810f\u7684\u8bc4\u4f30\u5916\uff0c\u80be\u810f\u6d3b\u68c0\u53ef\u5e2e\u52a9\u5668\u5b98\u8d28\u91cf\u7684\u8bc4\u4f30\u3002\u80be\u810f\u75c5\u7406\u6d3b\u68c0\u5c5e\u4e8e\u6709\u521b\u6027\u68c0\u67e5\uff0c\u662f\u5426\u4f5c\u4e3a\u4f9b\u4f53\u80be\u810f\u8bc4\u4f30\u7684\u5e38\u89c4\u68c0\u67e5\u76ee\u524d\u5b58\u5728\u4e89\u8bae[15] <\/sup>\u3002\u4f46\u80be\u6d3b\u68c0\u80fd\u5728\u8f83\u77ed\u7684\u65f6\u95f4\u5185\u5f97\u5230\u6162\u6027\u80be\u810f\u75be\u75c5\u7684\u75c5\u7406\u53d8\u5316 \uff08\u5982\uff1a\u80be\u5c0f\u7403\u786c\u5316 \uff08GS\uff09\u3001\u80be\u95f4\u8d28\u7ea4\u7ef4\u5316 \uff08IF\uff09\u3001\u80be\u8840\u7ba1\u6539\u53d8 \uff08VC\uff09\u7b49\uff09\u3002\u6162\u6027\u75c5\u7406\u53d8\u5316\u8d8a\u4e25\u91cd\uff0c\u79fb\u690d\u80be\u810f\u7684\u5de5\u4f5c\u5e74\u9650\u8d8a\u77ed\uff08\u56fe4\uff09\u3002\u6545\u4e34\u5e8a\u4e0a\u4ecd\u5728\u79fb\u690d\u524d\u5bf9\u201c\u8fb9\u7f18\u6027\u201d\u4f9b\u4f53\uff0c\u7279\u522b\u662f\u5b58\u5728\u6162\u6027\u80be\u810f\u75c5\u53f2\uff08\u5982\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u3001\u4f9b\u4f53\u624b\u672f\u524d\u80be\u529f\u80fd\u68c0\u67e5\u5b58\u5728\u5f02\u5e38\uff09\u7684\u80be\u810f\u5b9e\u65bd\u80be\u6d3b\u68c0\uff0c\u4ee5\u8bc4\u4f30\u6b64\u4f9b\u4f53\u80be\u810f\u80fd\u5426\u4f7f\u7528\uff0c\u5e76\u5c06\u75c5\u7406\u7ed3\u679c\u4f5c\u4e3a\u4f9b\u53d7\u4f53\u5339\u914d\u65f6\u7684\u8003\u8651\u56e0\u7d20[16] <\/sup>\u3002\u603b\u4f53\u6765\u8bf4\uff0c\u591a\u6570\u79fb\u690d\u4e2d\u5fc3\u628a\u5177\u6709GS\/IF\/VC\u635f\u4f24\u8d85\u8fc710%\u4f5c\u4e3a\u5b9e\u65bd\u80be\u79fb\u690d\u7684\u4e34\u754c\u503c\u3002<\/p>\n

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\u56fe4. \u4f9b\u4f53\u80be\u5c0f\u7403\u786c\u5316\u7387\u540c\u79fb\u690d\u540e<\/p>\n

\u80be\u810f\u5b58\u6d3b\u7684\u5173\u7cfb[16]<\/sup><\/p>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u4f9b\u4f53\u624b\u672f\u540e\u80be\u810f\u7684\u673a\u68b0\u704c\u6ce8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5229\u7528\u8fd1\u5e74\u53d1\u5c55\u8d77\u6765\u7684\u5668\u5b98\u673a\u68b0\u704c\u6ce8\u6280\u672f\u5305\u62ec\u4f53\u5185\u7684\u5e38\u6e29\u5c40\u90e8\u704c\u6ce8\uff08NRP\uff09\u548c\u4f53\u5916\u673a\u68b0\u704c\u6ce8 \uff08Ex situ machine perfusion, ESMP\uff09\uff0c\u53ef\u589e\u52a0\u8fb9\u7f18\u4f9b\u4f53\u5668\u5b98\u7684\u5229\u7528\u7387\uff0c\u5e76\u6539\u5584\u79fb\u690d\u540e\u7684\u4e34\u5e8a\u7ed3\u679c[13, 17]<\/sup>\u3002ESMP\u4e3b\u8981\u5206\u4e3a\u4f4e\u6e29\u673a\u68b0\u704c\u6ce8 \uff08HMP\uff09\u548c\u5e38\u6e29\u673a\u68b0\u704c\u6ce8 \uff08NMP\uff09\u3002<\/p>\n

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3.1 \u4f4e\u6e29\u673a\u68b0\u704c\u6ce8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f4e\u6e29\u673a\u68b0\u704c\u6ce8 \uff08HMP\uff09\u80fd\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u6539\u5584\u4f9b\u4f53\u80be\u810f\u7684\u8840\u6d41\u52a8\u529b\u5b66\uff0c\u704c\u6ce8\u671f\u95f4\u5c06\u53ef\u80fd\u5bf9\u80be\u810f\u4ea7\u751f\u635f\u5bb3\u7684\u7269\u8d28\uff08\u5982\u6c27\u81ea\u7531\u57fa\uff09\u5f15\u6d41\u51fa\u80be\u810f\uff0c\u6b64\u5916\u8fd8\u53ef\u5728\u704c\u6ce8\u671f\u95f4\u52a0\u5165\u6539\u5584\u80be\u810f\u529f\u80fd\u7684\u836f\u7269\uff08\u5982\u52a0\u5165\u8840\u7ba1\u8212\u5f20\u836f\u4ee5\u6539\u5584\u80be\u810f\u7684\u8840\u6d41\u52a8\u529b\u5b66\u6027\u80fd\uff09\u3002\u4f7f\u7528HMP\u80fd\u660e\u663e\u51cf\u5c11DGF\u7684\u53d1\u751f\u7387\uff0c\u5e76\u6539\u5584\u79fb\u690d\u540e\u4f9b\u80be\u76841\u5e74\u5b58\u6d3b\u7387\uff08\u56fe5\uff09 [17] <\/sup>.3\u5e74\u968f\u8bbf\u53d1\u73b0\uff0c\u76f8\u8f83\u4e8e\u4f20\u7edf\u9759\u6001\u51b7\u4fdd\u5b58\uff0c\u4f7f\u7528HMP\u4f7fECD\u4f9b\u80be\u7684\u5b58\u6d3b\u7387\u63d0\u9ad810%\u3002\u76ee\u524d\uff0c\u4f9b\u4f53\u80be\u810f\u7684\u4f53\u5916\u4f4e\u6e29\u673a\u68b0\u704c\u6ce8\u6280\u672f\u5df2\u4ece\u79d1\u7814\u5b9e\u9a8c\u9636\u6bb5\u9010\u6b65\u8fdb\u5165\u5230\u5e38\u89c4\u7684\u4e34\u5e8a\u5de5\u4f5c\u5e94\u7528\u9636\u6bb5<\/span><\/strong>[18]<\/sup> .<\/p>\n

\n<\/section>\n

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\n

\u56fe5. LifePort\u6539\u5584\u79fb\u690d\u540e\u4f9b\u4f53\u80be\u810f\u76841\u5e74\u5b58\u6d3b\u7387 \uff08p <0.05\uff09[17]<\/sup><\/p>\n

\u76ee\u524d\u4e34\u5e8a\u4e0a\u5e94\u7528\u6700\u5e7f\u7684HMP\u4e3aLifePort Kidney Transporter\u00ae\u00a0 <\/strong><\/span>\uff08\u56fe6\uff09\u3002\u81eaLifePort\u4e8e2003\u5e747\u6708\u83b7\u7f8e\u56fdFDA\u8bba\u8bc1\u5ba1\u6279\u540e [19] <\/sup>\u81f3\u4eca\uff0c\u5168\u7403\u5df2\u6709\u8d85\u8fc7175000\u4f8b\u4f9b\u4f53\u80be\u810f\u7ecf\u8fc7LifePort\u4f53\u5916\u673a\u68b0\u704c\u6ce8\u540e\u79fb\u690d\u5230\u4e86\u75c5\u4eba\u4f53\u5185\uff0c\u633d\u6551\u4e86\u75c5\u4eba\u7684\u751f\u547d[20] <\/sup>\u3002\u603b\u4f53\u6765\u8bf4\uff0c\u7f8e\u56fd\u8bb8\u591a\u79fb\u690d\u4e2d\u5fc3\u628aHMP 6 \u5c0f\u65f6\u540e\u80be\u8840\u6d41\u91cf <80 mL\/min \u548c\u80be\u8840\u7ba1\u963b\u529b >0.5 mmHg\/mL\/min \u4f5c\u4e3a\u63a5\u53d7\u6216\u4e0d\u63a5\u53d7\u6b64\u4f9b\u80be\u7684\u4e34\u754c\u503c\u3002<\/p>\n

\n<\/section>\n

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\n

\u56fe6. LifePort Kidney Transporter\u00ae<\/p>\n

\n<\/section>\n

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3.2 \u5e38\u6e29\u673a\u68b0\u704c\u6ce8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f9b\u4f53\u80be\u810f\u7684\u4f53\u5916\u5e38\u6e29\u673a\u68b0\u704c\u6ce8\uff08NMP\uff09\u6b63\u5728\u4e34\u5e8a\u79d1\u7814\u8bd5\u9a8c\u9636\u6bb5[21] <\/sup>\u3002\u521d\u671f\u7684\u7ed3\u679c\u8868\u660eNMP\u53ef\u8fdb\u4e00\u6b65\u5728\u79fb\u690d\u524d\u5bf9\u4f9b\u4f53\u80be\u810f\u8fdb\u884c\u8bc4\u4f30\uff0c\u589e\u52a0\u201c\u8fb9\u7f18\u6027\u201d \u4f9b\u80be\u7684\u5229\u7528\uff0c\u5e76\u6539\u5584\u79fb\u690d\u540e\u7684\u4e34\u5e8a\u7ed3\u679c [18, 22, 23]<\/sup>.<\/p>\n

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\u7ed3\u8bba\u00a0<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f8e\u56fd\u8fd1\u5e74\u6765\u6350\u732e\u6570\u548c\u79fb\u690d\u6570\u7684\u63d0\u5347\u79bb\u4e0d\u5f00\u8fb9\u7f18\u4f9b\u4f53\u7684\u5927\u91cf\u4f7f\u7528\u3002\u6ce8\u91cd\u8fb9\u7f18\u6027\u4f9b\u80be\u7684\u8d28\u91cf\u8bc4\u4f30\u3001\u4f9b\u4f53\u548c\u53d7\u4f53\u8fdb\u884c\u8f83\u4f73\u5339\u914d\u3001\u9009\u62e9\u6700\u4f73\u4f9b\u4f53\u624b\u672f\u65b9\u6848\u4ee5\u53ca\u4f9b\u4f53\u672f\u540e\u5229\u7528\u4f53\u5916\u673a\u68b0\u704c\u6ce8\u6280\u672f\u7b49\u65b9\u6848\u53ef\u589e\u52a0\u8fb9\u7f18\u6027\u4f9b\u80be\u7684\u5229\u7528\u7387\uff0c\u5e76\u8fdb\u4e00\u6b65\u6539\u5584\u79fb\u690d\u540e\u7684\u4e34\u5e8a\u7ed3\u5c40\u3002<\/p>\n

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Referances<\/p>\n

[1] Ravaioli M, De Pace V, Angeletti A, et al. Author Correction: Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors: First Italian Clinical Trial [J]. Sci Rep, 2020, 10(1): 14658. \u00a0DOI: 10.1038\/s41598-020-70620-y.<\/p>\n

[2]Unos. 2022 organ transplants again set annual records [M]. 2023: https:\/\/unos.org\/news\/2022-organ-transplants-again-set-annual-records\/.<\/p>\n

[3]Americankidneyfund. Transplant waiting list [M]. 2023: https:\/\/www.kidneyfund.org\/kidney-donation-and-transplant\/transplant-waiting-list.<\/p>\n

[4]Maggiore U, Cravedi P. The marginal kidney donor [J]. Current opinion in organ transplantation, 2014, 19(4): 372-380. \u00a0DOI: 10.1097\/mot.0000000000000081.<\/p>\n

[5]Noble J, Jouve T, Malvezzi P, et al. Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives in Kidney Transplantation [J]. Front Immunol, 2019, 10(3142. \u00a0DOI: 10.3389\/fimmu.2019.03142.<\/p>\n

[6]Warmuzi\u0144ska N, \u0141uczykowski K, Bojko B. A Review of Current and Emerging Trends in Donor Graft-Quality Assessment Techniques [J]. Journal of clinical medicine, 2022, 11(3). \u00a0DOI: 10.3390\/jcm11030487.<\/p>\n

[7]Rao PS, Ojo A. The alphabet soup of kidney transplantation: SCD, DCD, ECD–fundamentals for the practicing nephrologist [J]. Clin J Am Soc Nephrol, 2009, 4(11): 1827-1831. \u00a0DOI: 10.2215\/cjn.02270409.<\/p>\n

[8]Sharif A. Deceased Donor Characteristics and Kidney Transplant Outcomes [J]. Transplant international : official journal of the European Society for Organ Transplantation, 2022, 35(10482. \u00a0DOI: 10.3389\/ti.2022.10482.<\/p>\n

[9]Optn. Kidney Donor Profile Index (KDPI) Guide for Clinicians [M]. 2023: https:\/\/optn.transplant.hrsa.gov\/professionals\/by-topic\/guidance\/kidney-donor-profile-index-kdpi-guide-for-clinicians\/.<\/p>\n

[10]Dahmen M, Becker F, Pavenst\u00e4dt H, et al. Validation of the Kidney Donor Profile Index (KDPI) to assess a deceased donor’s kidneys’ outcome in a European cohort [J]. Sci Rep, 2019, 9(1): 11234. \u00a0DOI: 10.1038\/s41598-019-47772-7.<\/p>\n

[11]Hessheimer AJ, Polak W, Antoine C, et al. Regulations and Procurement Surgery in DCD Liver Transplantation: Expert Consensus Guidance From the International Liver Transplantation Society [J]. Transplantation, 2021, 105(5): 945-951. \u00a0DOI: 10.1097\/tp.0000000000003729.<\/p>\n

[12]Alamouti-Fard E, Garg P, Wadiwala IJ, et al. Normothermic Regional Perfusion is an Emerging Cost-Effective Alternative in Donation After Circulatory Death (DCD) in Heart Transplantation [J]. Cureus, 2022, 14(6): e26437. \u00a0DOI: 10.7759\/cureus.26437.<\/p>\n

[13]Bekki Y, Croome KP, Myers B, et al. Normothermic Regional Perfusion Can Improve Both Utilization and Outcomes in DCD Liver, Kidney, and Pancreas Transplantation [J]. Transplantation direct, 2023, 9(3): e1450. \u00a0DOI: 10.1097\/txd.0000000000001450.<\/p>\n

[14]Zhou AL, Leng A, Ruck JM, et al. Kidney Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion: The Largest Report of the United States Experience [J]. Transplantation, 2023, 10.1097\/TP.0000000000004801. \u00a0DOI: 10.1097\/tp.0000000000004801.<\/p>\n

[15]Lentine KL, Fleetwood VA, Caliskan Y, et al. Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision-Making: A Survey of US Kidney Transplant Centers [J]. Kidney Int Rep, 2022, 7(6): 1268-1277. \u00a0DOI: 10.1016\/j.ekir.2022.03.021.<\/p>\n

[16]Stewart DE, Foutz J, Kamal L, et al. The Independent Effects of Procurement Biopsy Findings on 10-Year Outcomes of Extended Criteria Donor Kidney Transplants [J]. Kidney Int Rep, 2022, 7(8): 1850-1865. \u00a0DOI: 10.1016\/j.ekir.2022.05.027.<\/p>\n

[17]Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation [J]. The New England journal of medicine, 2009, 360(1): 7-19. \u00a0DOI: 10.1056\/NEJMoa0802289.<\/p>\n

[18]L\u00f3pez-Mart\u00ednez S, Sim\u00f3n C, Santamaria X. Normothermic Machine Perfusion Systems: Where Do We Go From Here? [J]. Transplantation, 2023. \u00a0DOI: 10.1097\/tp.0000000000004573.<\/p>\n

[19]Signa. Kidney Transplantation, Pancreas-Kidney Transplantation, and Pancreas Transplantation Alone [M]. Medical Coverage Policy. 2023: 0146.<\/p>\n

[20]Medicaldesigndevelopment. LifePort Kidney Transporter Awarded Exclusive Contract in Belgium [M]. 2023: https:\/\/www.medicaldesigndevelopment.com\/topics\/surgical\/news\/22485822\/lifeport-kidney-transporter-awarded-exclusive-contract-in-belgium.<\/p>\n

[21]Choudhary D, Sharma A, Singh S, et al. Application of Ex Vivo Normothermic Machine Perfusion in Deceased Donors With Acute Kidney Injury With Successful Renal Transplantation: A Preliminary Experience [J]. Transplantation direct, 2022, 8(11): e1391. \u00a0DOI: 10.1097\/txd.0000000000001391.<\/p>\n

[22]Fard A, Pearson R, Lathan R, et al. Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review [J]. Transplant international : official journal of the European Society for Organ Transplantation, 2022, 35(10236. \u00a0DOI: 10.3389\/ti.2022.10236.<\/p>\n

[23]Zulpaite R, Miknevicius P, Leber B, et al. Ex-vivo Kidney Machine Perfusion: Therapeutic Potential [J]. Front Med (Lausanne), 2021, 8(808719. \u00a0DOI: 10.3389\/fmed.2021.808719.<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n<\/section>\n

\n<\/div>","protected":false},"excerpt":{"rendered":"

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