{"id":3880,"date":"2023-06-30T14:28:57","date_gmt":"2023-06-30T06:28:57","guid":{"rendered":"https:\/\/transnovo.com\/news\/%e4%bb%96%e5%85%8b%e8%8e%ab%e5%8f%b8%e6%b5%93%e5%ba%a6%e7%9b%91%e6%b5%8b%e5%9c%a8%e8%82%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%9a%84%e5%ba%94%e7%94%a8\/"},"modified":"2023-06-30T14:28:57","modified_gmt":"2023-06-30T06:28:57","slug":"%e4%bb%96%e5%85%8b%e8%8e%ab%e5%8f%b8%e6%b5%93%e5%ba%a6%e7%9b%91%e6%b5%8b%e5%9c%a8%e8%82%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%9a%84%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/%e4%bb%96%e5%85%8b%e8%8e%ab%e5%8f%b8%e6%b5%93%e5%ba%a6%e7%9b%91%e6%b5%8b%e5%9c%a8%e8%82%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%9a%84%e5%ba%94%e7%94%a8\/","title":{"rendered":"Tacrolimus concentration monitoring in the field of nephrology"},"content":{"rendered":"
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\u4ed6\u514b\u83ab\u53f8\uff08Tacrolimus\uff09<\/span><\/strong>\uff0c\u53c8\u540dFK506<\/strong><\/span>\uff0c\u662f<\/span><\/span>\u4e00\u79cd\u4ece\u571f\u58e4\u771f\u83cc\u7684\u53d1\u9175\u6db2\u4e2d\u63d0\u53d6\u5206\u79bb\u5f97\u5230\u7684\u5927\u73af\u5185\u916f\u7c7b\u6297\u83cc\u836f\u7269<\/span>\uff0c\u5c5e\u4e8e\u9499\u8c03\u78f7\u9178\u9176\u6291\u5236\u5242<\/span><\/strong>\uff0c\u5728\u4e34\u5e8a\u4e3b\u8981\u5c06\u5176\u7528\u4e8e\u809d\u3001\u80be\u79fb\u690d\u672f\u540e\u6297\u6392\u65a5\u53cd\u5e94\u7684\u4e00\u7ebf\u7528\u836f<\/span><\/strong>[1]<\/sup>.<\/span><\/p>\n


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\u4e3b\u8981<\/span>\u901a\u8fc7\u4e0eT\u6dcb\u5df4\u7ec6\u80de\u5185\u7684FK506\u53d7\u4f53\u7ed3\u5408\u86cb\u767d-12\uff08FKBP-12\uff09\u7ed3\u5408\uff0c\u5f62\u6210Tac-FKBP-12\u590d\u5408\u4f53\uff0c\u8be5\u590d\u5408\u4f53\u4e0e\u9499\u8c03\u78f7\u9178\u9176\u7ed3\u5408\uff0c\u5e76\u6291\u5236\u540e\u8005\u7684\u6d3b\u5316\u3002<\/span>\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5e72\u6270\u3001\u6291\u5236\u767d\u7ec6\u80de\u4ecb\u7d202\uff08IL-2\uff09\u7684\u5408\u6210\uff0c\u51cf\u5c11\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u5411\u79fb\u690d\u7269\u7684\u6d78\u6da6\uff0c\u4ece\u800c\u8fbe\u5230\u9884\u9632\u548c\uff08\u6216\uff09\u6cbb\u7597\u6392\u65a5\u53cd\u5e94\u7684\u76ee\u7684\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u4e8e\u4ed6\u514b\u83ab\u53f8\u5177\u6709\u80be\u6bd2\u6027\u548c\u795e\u7ecf\u6bd2\u6027\u7b49\u4e0d\u826f\u53cd\u5e94\uff0c\u4e14\u548c\u7528\u836f\u5242\u91cf\u5448\u76f8\u5173\u6027\uff0c\u6cbb\u7597\u7a97\u8f83\u7a84\uff0c\u836f\u52a8\u5b66\u4e2a\u4f53\u5dee\u5f02\u5927\uff0c\u7ed9\u4e88\u540c\u6837\u5242\u91cf\u7684\u4ed6\u514b\u83ab\u53f8\u4f1a\u51fa\u73b0\u4e0d\u540c\u7684\u8840\u836f\u6d53\u5ea6\uff0c<\/span>\u9700\u8981\u5bf9\u5176\u8840\u836f\u6d53\u5ea6\u8fdb\u884c\u76d1\u6d4b<\/span>[2]<\/sup>.<\/span><\/p>\n


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In addition.\u80be\u75c5\u672c\u8eab\u5c31\u4f1a\u5f71\u54cd\u4ed6\u514b\u83ab\u53f8\u5728\u4f53\u5185\u7684\u4ee3\u8c22\u548c\u6392\u6cc4<\/span><\/strong>\u3002\u80be\u529f\u80fd\u53d7\u635f\u4f1a\u5bfc\u81f4\u836f\u7269\u6392\u6cc4\u901f\u5ea6\u4e0b\u964d\uff0c\u836f\u7269\u5728\u4f53\u5185\u7684\u534a\u8870\u671f\u589e\u52a0\uff0c\u4ece\u800c\u589e\u52a0\u836f\u7269\u5728\u4f53\u5185\u7684\u7d2f\u79ef\uff0c\u5bfc\u81f4\u836f\u7269\u6d53\u5ea6\u5347\u9ad8\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u80be\u75c5\u60a3\u8005\uff0c\u7279\u522b\u662f\u80be\u529f\u80fd\u53d7\u635f\u8f83\u4e3a\u4e25\u91cd\u7684\u60a3\u8005\uff0c\u68c0\u6d4b\u4ed6\u514b\u83ab\u53f8\u7684\u6d53\u5ea6\u53ef\u4ee5\u66f4\u597d\u5730\u8bc4\u4f30\u836f\u7269\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u907f\u514d\u836f\u7269\u7684\u8fc7\u91cf\u4f7f\u7528\u548c\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f<\/span><\/strong>.<\/span><\/p>\n

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\u5728\u56fd\u5185\u5916\u53d1\u5e03\u591a\u90e8\u4ed6\u514b\u83ab\u53f8\u7684\u4e34\u5e8a\u7528\u836f\u6307\u5357[3]<\/sup>\u4e5f\u90fd\u63a8\u8350<\/span>\u8fdb\u884c\u6cbb\u7597\u836f\u7269\u76d1\u6d4b\uff08TDM\uff0cTherapeutic Drug Monitoring\uff09<\/span><\/strong><\/span>.<\/span><\/p>\n


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\u819c\u6027\u80be\u75c5\u6cbb\u7597\u5c1a\u65e0\u516c\u8ba4\u7684\u6700\u4f73\u65b9\u6848\uff0c<\/span>\u4e34\u5e8a\u4e0a\u4e3b\u8981\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u4f20<\/span>\u7edf\u6cbb\u7597\u65b9\u6848\u4e3a\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8054\u5408\u73af\u78f7\u9170\u80fa\u6216\u82ef\u4e01\u9178\u6c2e\u82a5\u6cbb\u7597\uff0c\u5177\u6709\u8f83\u5927\u7684\u4e0d\u826f\u53cd\u5e94\u4e14\u53ea\u5bf9\u90e8\u5206\u60a3\u8005\u6709\u6548\u3002<\/span>\u5e94\u7528\u4ed6\u514b\u83ab\u53f8\u8054\u5408\u5c0f\u5242\u91cf\u6cfc\u5c3c\u677e\u819c\u6027\u80be\u75c5\u53d6\u5f97\u4e86\u8f83\u597d\u7684\u6548\u679c\u3002<\/span><\/strong><\/span><\/p>\n

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41\u4f8b<\/span>\u539f\u53d1\u6027\u819c\u6027\u80be\u75c5\u7684<\/span>\u7814\u7a76[4]<\/sup>\u663e\u793a\uff0c\u6240\u6709\u60a3\u8005\u5747\u91c7\u7528FK506\u8054\u5408\u5c0f\u5242\u91cf\u6cfc\u5c3c\u677e\u6cbb\u7597<\/span><\/strong>\uff0cFK506\u521d\u59cb\u7ed9\u836f\u5242\u91cf0.05mg\/\uff08kg\u00b7d\uff09\u3002\u5f53FK506\u8fbe\u5230\u7a33\u6001\u8840\u836f\u6d53\u5ea6\u540e\uff0c\u5728\u7ed9\u836f\u6cbb\u7597\u540e\u76841\u30012\u5468\u53ca1\u30012\u30013\u30016\u4e2a\u6708\u6d4b\u5b9a<\/span>\u5168\u8840\u8c37\u6d53\u5ea6\uff08C0<\/sub><\/strong>)<\/strong>\uff0c\u540c\u65f6\u68c0\u6d4b\u8840\u5e38\u89c4\u3001\u5c3f\u86cb\u767d\u3001\u767d\u86cb\u767d\u3001\u6c34\u80bf\u7a0b\u5ea6\u3001\u809d\u80be\u529f\u80fd\u53ca\u51dd\u8840\u529f\u80fd\u4e94\u9879\uff0c\u8fdb\u884c\u4e34\u5e8a\u7597\u6548\u8bc4\u4ef7\u3002<\/span><\/p>\n


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\u7814\u7a76\u63d0\u793a\uff0cFK506 <\/span>\u5728\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7ec4\u8840\u836f\u6d53\u5ea6\u6700\u9ad8\uff0c\u5176\u6b21\u4e3a\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u7ec4\uff0c\u65e0\u7f13\u89e3\uff08NR\uff09\u7ec4<\/span>\u660e\u663e\u4f4e\u4e8e\u524d\u4e8c\u8005\u3002\u4e09\u8005\u4e24\u4e24\u6bd4\u8f83\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49(P<0.05)\u3002\u8bf4\u660e\u8840\u836f\u6d53\u5ea6\u662f\u5f71\u54cd FK506 \u4e34\u5e8a\u7597\u6548\u7684\u4e3b\u8981\u56e0\u7d20\u3002<\/span><\/strong>FK506\u6cbb\u7597\u819c\u6027\u80be\u75c5\u7684\u4e34\u5e8a\u7597\u6548\u4e0e\u8840\u836f\u6d53\u5ea6\u5448\u6b63\u76f8\u5173\uff0c\u6709\u6548\u7684\u8840\u836f\u6d53\u5ea6\u8303\u56f4\u4e3a4.53~10.21 ng\/ml\u3002<\/span><\/p>\n


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TDM\u5728\u80be\u75c5\u7efc\u5408\u5f81\u4e2d\u7684\u610f\u4e49<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u300aInternational Immunopharmacology\u300b\u53d1\u8868\u7684\u4e00\u9879\u513f\u7ae5\u96be\u6cbb\u6027\u80be\u75c5\u7efc\u5408\u5f81\u7684\u56de\u987e\u6027\u7814\u7a76[5]<\/sup>\uff0c\u7eb3\u5165\u4e862016\u5e741\u6708\u81f32018\u5e745\u6708\u5357\u4eac\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u513f\u7ae5\u533b\u9662\u786e\u8ba4\u4e3a\u96be\u6cbb\u6027\u80be\u75c5\u7efc\u5408\u5f81\u7684118\u4f8b\u60a3\u513f\u3002\u5728\u6574\u4e2a\u6cbb\u7597\u65f6\u95f4\u8303\u56f4\u5185\u76d1\u6d4b\u8840\u6db2C0<\/sub>\uff0c\u603b\u5171\u5bf9118\u540d\u60a3\u8005\u8fdb\u884c\u4e86785\u6b21\u6d4b\u91cf,\u53d1\u73b0C0<\/sub>\u503c<\/span>\u4ecb\u4e8e1<\/span>.3\u548c14.2 ng\/mL (\u542b)\u3002\u53ea\u6709 <\/span>35 \u540d\u60a3\u8005(29.7%)\u8fbe\u5230\u4e86 KDIGO \u6307\u5357\u63a8\u8350\u7684\u76ee\u6807\u8840\u6db2\u6c34\u5e73(5-10ng\/mL)\u3002<\/span>\u901a\u8fc7\u5bf9\u4ed6\u514b\u83ab\u53f8\u6d53\u5ea6\u76d1\u6d4b\u5e76\u5242\u91cf\u8c03\u6574\u540e\uff0c\u603b\u5171 59 \u540d\u60a3\u8005(50%) \u7684C0<\/sub>\u503c(5.0-9.6 ng\/mL) \u8fbe\u5230\u63a8\u8350\u6c34\u5e73\u3002<\/strong><\/p>\n


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\u7814\u7a76\u663e\u793a\uff0c<\/span>\u8f83\u4f4e\u5242\u91cf\u7684\u4ed6\u514b\u83ab\u53f8\u8054\u5408\u6cfc\u5c3c\u677e\u53ef\u4ee5\u7ef4\u6301\u96be\u6cbb\u6027\u80be\u75c5\u7efc\u5408\u5f81\u60a3\u513f\u7684\u75c5\u60c5\u7f13\u89e3\uff0c\u76d1\u6d4b\u4ed6\u514b\u83ab\u53f8\u8840\u836f\u6d53\u5ea6\u53ef\u4ee5\u907f\u514d\u9ad8\u836f\u7269\u6d53\u5ea6\u5f15\u8d77\u7684\u6bd2\u6027\uff0c\u540c\u65f6\u4f7f\u4ed6\u514b\u83ab\u53f8\u7ef4\u6301\u5728\u4f4e\u5242\u91cf<\/span><\/strong><\/span>.<\/span><\/p>\n


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\u5728\u80be\u75c5\u9886\u57df\uff0c\u901a\u8fc7\u76d1\u6d4b\u4ed6\u514b\u83ab\u53f8\u7684\u8840\u836f\u6d53\u5ea6\uff0c\u53ef\u4ee5\u5b9e\u73b0\u4ee5\u4e0b\u76ee\u7684\uff1a<\/span><\/p>\n

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\u786e\u5b9a\u9002\u5b9c\u7684\u5242\u91cf<\/span><\/strong>\uff1a\u6839\u636e\u60a3\u8005\u7684\u4e2a\u4f53\u5dee\u5f02\u548c\u836f\u7269\u4ee3\u8c22\u60c5\u51b5\uff0c\u8c03\u6574\u4ed6\u514b\u83ab\u53f8\u7684\u5242\u91cf\uff0c\u4f7f\u5176\u8fbe\u5230\u6cbb\u7597\u6548\u679c\u5e76\u907f\u514d\u526f\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u76d1\u6d4b\u6cbb\u7597\u6548\u679c<\/span><\/strong>\uff1a\u4ed6\u514b\u83ab\u53f8\u7684\u8840\u836f\u6d53\u5ea6\u4e0e\u6cbb\u7597\u6548\u679c\u4e4b\u95f4\u5b58\u5728\u4e00\u5b9a\u7684\u5173\u7cfb\uff0c\u901a\u8fc7\u76d1\u6d4b\u8840\u836f\u6d53\u5ea6\u53ef\u4ee5\u8bc4\u4f30\u6cbb\u7597\u6548\u679c\u5e76\u53ca\u65f6\u8c03\u6574\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9884\u9632\u4e0d\u826f\u53cd\u5e94<\/span><\/strong>\uff1a\u4ed6\u514b\u83ab\u53f8\u7684\u4e0d\u826f\u53cd\u5e94\u4e0e\u8840\u836f\u6d53\u5ea6\u6709\u5173\uff0c\u901a\u8fc7\u76d1\u6d4b\u8840\u836f\u6d53\u5ea6\u53ef\u4ee5\u907f\u514d\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u603b\u4e4b\uff0c\u76d1\u6d4b\u4ed6\u514b\u83ab\u53f8\u7684\u8840\u836f\u6d53\u5ea6<\/span><\/strong>\u5728\u80be\u75c5\u9886\u57df\u7684\u5e94\u7528\u975e\u5e38\u5e7f\u6cdb\uff0c\u53ef\u4ee5\u5e2e\u52a9\u533b\u751f\u5236\u5b9a\u66f4\u52a0\u4e2a\u4f53\u5316\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u5e76\u9884\u9632\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f<\/span><\/strong>.<\/span><\/p>\n


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[1] \u4e2d\u534e\u533b\u5b66\u4f1a\u5668\u5b98\u79fb\u690d\u5b66\u5206\u4f1a\u80be\u79fb\u690d\u5b66\u7ec4. \u4ed6\u514b\u83ab\u53f8\u5728\u4e34\u5e8a\u80be\u79fb\u690d\u4e2d\u7684\u5e94\u7528\u6307\u5357[J]. \u4e2d\u534e\u5668\u5b98\u79fb\u690d\u6742\u5fd7, 2010, 31\uff089\uff09: 565-566.<\/span><\/p>\n

[2]\u9648\u6587\u5029,\u5f20\u96f7,\u5f20\u5f0b,\u5b59\u4e3d\u83b9,\u9648\u6587\u6167,\u9ec4\u6d01,\u738b\u5353,\u738b\u6653\u661f,\u674e\u6cad,\u67f3\u82b3,\u5ed6\u4e2d\u51ef,\u5f20\u76f8\u6797.\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u4ed6\u514b\u83ab\u53f8\u4e2a\u4f53\u5316\u6cbb\u7597\u4e13\u5bb6\u5171\u8bc6[J].\u5b9e\u7528\u5668\u5b98\u79fb\u690d\u7535\u5b50\u6742\u5fd7,2022,10(04):301-308.<\/span><\/p>\n

[3]Wallemacq P , Armstrong V W , Brunet M , et al. Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference.[J]. Ther Drug Monit, 2009(2).<\/span><\/p>\n

[4]\u53f6\u51ac\u6885,\u5434\u6f6e\u6e05,\u7533\u5e86\u8363,\u91d1\u96ea\u5cf0.\u4ed6\u514b\u83ab\u53f8\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b\u5728\u819c\u6027\u80be\u75c5\u6cbb\u7597\u4e2d\u7684\u610f\u4e49[J].\u4e2d\u56fd\u836f\u623f,2015,26(26):3649-3651.<\/span><\/p>\n

[5] Guo HL, Xu J, Sun JY, Li L, Guo HL, Jing X, Xu ZY, Hu YH, Xu ZJ, Sun F, Ding XS, Chen F, Zhao F. Tacrolimus treatment in childhood refractory nephrotic syndrome: A retrospective study on efficacy, therapeutic drug monitoring, and contributing factors to variable blood tacrolimus levels. Int Immunopharmacol. 2020 Apr;81:106290.<\/span><\/p>\n


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