{"id":3305,"date":"2020-08-06T20:00:00","date_gmt":"2020-08-06T12:00:00","guid":{"rendered":"https:\/\/transnovo.com\/news\/%e3%80%90ajt%e7%89%b9%e5%88%8a%e3%80%91%e7%8e%b0%e7%8a%b6%e4%b8%8e%e6%8c%91%e6%88%98%ef%bc%9a%e5%a6%82%e4%bd%95%e9%a2%84%e9%98%b2%e5%92%8c%e6%b2%bb%e7%96%97%e8%82%be%e7%a7%bb%e6%a4%8d%e4%b8%ad\/"},"modified":"2020-08-06T20:00:00","modified_gmt":"2020-08-06T12:00:00","slug":"%e3%80%90ajt%e7%89%b9%e5%88%8a%e3%80%91%e7%8e%b0%e7%8a%b6%e4%b8%8e%e6%8c%91%e6%88%98%ef%bc%9a%e5%a6%82%e4%bd%95%e9%a2%84%e9%98%b2%e5%92%8c%e6%b2%bb%e7%96%97%e8%82%be%e7%a7%bb%e6%a4%8d%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/%e3%80%90ajt%e7%89%b9%e5%88%8a%e3%80%91%e7%8e%b0%e7%8a%b6%e4%b8%8e%e6%8c%91%e6%88%98%ef%bc%9a%e5%a6%82%e4%bd%95%e9%a2%84%e9%98%b2%e5%92%8c%e6%b2%bb%e7%96%97%e8%82%be%e7%a7%bb%e6%a4%8d%e4%b8%ad\/","title":{"rendered":"[AJT Special Issue] Status and Challenges: How to Prevent and Treat Antibody-Mediated Rejection in Renal Transplantation"},"content":{"rendered":"
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\u4f9b\u8005\u7279\u5f02\u6027\u6297\u4f53(DSA)\u7684\u98ce\u9669\u56e0\u7d20\u548c\u5f71\u54cd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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(1)<\/span><\/strong> \u4ec5\u901a\u8fc7\u56fa\u76f8 SAB \uff08\u5355\u6297\u539f\u78c1\u73e0\u6cd5\uff09\u53ef\u68c0\u6d4b\u5230\u7684\u4f4e\u6ef4\u5ea6\u7684DSA\u53ef\u5f15\u8d77 ABMR\uff1b
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dn DSA\uff08\u65b0\u53d1 DSA\uff09\u76f8\u5173\u7684ABMR<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u76ee\u524d\u5c1a\u65e0 FDA \u6279\u51c6\u7684 ABMR \u7597\u6cd5 \uff0c\u800c\u4e14\u65e9\u671f\u548c\u665a\u671f ABMR \u7684\u8868\u578b\u4e0d\u540c\uff0c\u6cbb\u7597\u53cd\u5e94\u6027\u548c\u7ed3\u5c40\u4e5f\u4e0d\u540c\u3002\u9274\u4e8e\u8fd9\u4e9b\u9650\u5236\uff0cTTS\u4e8e 2019 \u5e74\u53ec\u5f00\u4e86\u4e00\u4e2a\u4e13\u5bb6\u5171\u8bc6\u5de5\u4f5c\u7ec4\u4f1a\u8bae\uff0c\u5236\u5b9a\u4e86 ABMR \u7684\u63a8\u8350\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n

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\u65e9\u671f\u6d3b\u52a8\u6027 ABMR\uff08\u79fb\u690d< 30 \u5929\uff09\u4e0eDSA \u76f8\u5173<\/strong><\/p>\n<\/section>\n<\/section>\n

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TTS \u5de5\u4f5c\u7ec4\u4e0eFDA \u7814\u8ba8\u4f1a\u4e00\u81f4\uff0c\u5efa\u8bae\u5c06\u8840\u6d46\u7f6e\u6362\u3001IVIg \u548c\u76ae\u8d28\u7c7b\u56fa\u9187\u7684\u8054\u5408\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\uff0c\u4ee5\u53bb\u9664\u5faa\u73afDSA \u548c\/\u6216\u51cf\u5c11 DSA \u751f\u6210\u3002<\/p>\n

\u5728 FDA \u7814\u8ba8\u4f1a\u4e2d\u63d0\u5230\u7684\u201c\u6bcf\u4e2a\u4e2d\u5fc3\u504f\u597d\u4e0d\u540c\u7684\u8f85\u52a9\u6cbb\u7597\u201d\uff0c\u88ab TTS \u5de5\u4f5c\u7ec4\u8ba4\u4e3a\u662f\u6709\u4e89\u8bae\u7684\uff0c\u4f46\u5728\u6025\u6027\u79fb\u690d\u7269\u4e22\u5931\u98ce\u9669\u8f83\u9ad8\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u80fd\u9700\u8981\u8f85\u52a9\u6cbb\u7597\uff1a\u5305\u62ec\u5229\u59a5\u6614\u5355\u6297\uff08\u6297CD20\u5355\u6297\uff09\u3001\u8865\u4f53\u6291\u5236\u5242\uff08\u5982 eculizumab\uff09\u548c\u813e\u5207\u9664\u672f\u3002<\/p>\n<\/section>\n

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\u665a\u671f\u6d3b\u52a8\u6027\u548c\u6162\u6027\u6d3b\u52a8\u6027 ABMR\uff08\u79fb\u690d\u540e > 30 \u5929\uff09<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/p>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u5bf9\u4e8e\u9884\u5b58DSA \u76f8\u5173\u7684\u665a\u671f\u6d3b\u52a8\u6027 ABMR\uff0cTTS \u5de5\u4f5c\u7ec4\u7684\u5171\u8bc6\u63a8\u8350\u4ecd\u7136\u662f\u8840\u6d46\u7f6e\u6362\u3001IVIg \u548c\u76ae\u8d28\u7c7b\u56fa\u9187\uff0c\u53ef\u4ee5\u8003\u8651\u5229\u59a5\u6614\u5355\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n

\u7136\u800c\uff0c\u4e00\u65e6\u8bb0\u5fc6\u76f8\u5173\u7684ABMR\u6f14\u53d8\u4e3a\u6162\u6027\u6d3b\u52a8\u578b\uff0c\u8003\u8651\u5230\u514d\u75ab\u6291\u5236\u8fc7\u5ea6\u7684\u98ce\u9669\uff08\u6ca1\u6709\u4efb\u4f55\u836f\u7269\u7684\u6709\u6548\u6027\u8bc1\u660e\uff09\u5de5\u4f5c\u7ec4\u503e\u5411\u4e8e\u8003\u8651\u652f\u6301\u6cbb\u7597\uff0c\u540c\u65f6\u4f18\u5316\u57fa\u7840\u514d\u75ab\u6291\u5236\u65b9\u6848\uff08\u5373\u4ed6\u514b\u83ab\u53f8\u8c37\u503c>5.0 ng\/mL\uff09\u3002<\/p>\n

dn DSA\u76f8\u5173\u7684\u6d3b\u52a8\u6027\u548c\u6162\u6027\u6d3b\u52a8\u6027 ABMR \u901a\u5e38\u662fTCMR\/ABMR \u6df7\u5408\u8868\u578b\uff0c\u4e3b\u8981\u5f52\u56e0\u4e8e\u514d\u75ab\u6291\u5236\u4e0d\u8db3\uff0c\u901a\u5e38\u96be\u4ee5\u9006\u8f6c\u3002\u56e0\u6b64\uff0cTTS \u5de5\u4f5c\u7ec4\u5efa\u8bae\u4f18\u5316\u57fa\u7840\u514d\u75ab\u6291\u5236\uff0c\u5e76\u6cbb\u7597TCMR\u3002\u8840\u6d46\u7f6e\u6362\u3001IVIg \u548c\u5229\u59a5\u6614\u5355\u6297\u7684\u6cbb\u7597\u8bc1\u636e\u88ab\u8ba4\u4e3a\u592a\u4f4e\uff0c\u4e0d\u63a8\u8350\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\uff0c\u4f46\u53ef\u8003\u8651\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n


<\/p>\n<\/section>\n

\n
\n
\n

\u8f85\u52a9\u548c\u65b0\u5174\u6cbb\u7597\u63aa\u65bd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

\u56fe2 ABMR\u7684\u6548\u5e94\u673a\u5236<\/span><\/p>\n


<\/p>\n<\/section>\n

\n
\n
<\/section>\n
\n

\u6297\u8865\u4f53<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/p>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u5728 ABMR \u4e2d\uff0c\u8865\u4f53\u9014\u5f84\u662f\u901a\u8fc7\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08\u5982C5-C9 \u819c\u653b\u51fb\u590d\u5408\u7269\uff09\u548c C3a\/C3b\/C5a \u4ecb\u5bfc\u7684\u5185\u76ae\u6d3b\u5316\/\u708e\u6027\u7ec6\u80de\u8d8b\u5316\u5bfc\u81f4\u7ec4\u7ec7\u635f\u4f24\u7684\u4e3b\u8981\u6548\u5e94\u9014\u5f84\u3002<\/p>\n

\u5728\u4e00\u9879 eculizumab\uff08\u6297C5\u5355\u6297\uff09\u6cbb\u7597dn DSA\u76f8\u5173 ABMR \u7684\u521d\u6b65 RCT\u7814\u7a76\u4e2d\uff0c\u80be\u529f\u80fd\u6709\u7a33\u5b9a\u7684\u8d8b\u52bf\uff0c\u4f46\u5185\u76ae\u6d3b\u5316\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\u672a\u53d7\u5f71\u54cd\u3002\u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a C5 \u88ab\u6291\u5236\u4f7f\u65e9\u671f\u4fc3\u708e\u6027\u8865\u4f53\u4ecb\u8d28\uff08\u4f8b\u5982C3a\/C3b\uff09\u65e0\u5bf9\u6297\u4f5c\u7528\uff0c\u800c\u540e\u8005\u53ef\u6fc0\u6d3b\u5185\u76ae\u3002<\/p>\n

\u5df4\u9ece\u5c0f\u7ec4\u5728\u6807\u51c6\u6cbb\u7597\uff08\u5373\u8840\u6d46\u7f6e\u6362\u3001IVIg\u3001\u5229\u59a5\u6614\u5355\u6297\uff09\u65e0\u6548\u7684\u6d3b\u52a8\u6027 ABMR \u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u4e00\u9879\u4e3a\u671f 6 \u4e2a\u6708\u7684 C1 \u6291\u5236\u5242 (INH) + IVIg \u7684\u524d\u77bb\u6027\u3001\u5355\u81c2\u7814\u7a76\uff0c\u7ed3\u679c\u663e\u793a\u80be\u529f\u80fd\u663e\u8457\u6539\u5584\uff0c\u540c\u65f6\u5b89\u5168\u6027\u5c1a\u53ef\u3002\u53e6\u5916\uff0c\u4e00\u9879\u7f8e\u56fd\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167 RCT \u521d\u63a2\u6027\u7814\u7a76\uff0c\u6bd4\u8f83\u4e86 C1-INH \u4e0e\u5b89\u6170\u5242\u4f5c\u4e3a\u8840\u6d46\u7f6e\u6362\u7684\u8f85\u52a9\u6cbb\u7597\uff0c\u540c\u6837\u89c2\u5bdf\u5230\u4e86\u80be\u529f\u80fd\u6539\u5584\u548c\u66f4\u5c11\u7684\u79fb\u690d\u80be\u5c0f\u7403\u75c5\u8d8b\u52bf\u3002<\/p>\n

\u8fd9\u4e9b\u7814\u7a76\u5145\u5206\u8868\u660e\u4e86\u6297\u8865\u4f53\u7684\u6f5c\u5728\u7597\u6548\uff0c\u4f46\u4ecd\u9700\u6b63\u5f0f\u5927\u89c4\u6a21\u7684RCT\u8fdb\u4e00\u6b65\u7814\u7a76\u8865\u4f53\u6291\u5236\u7597\u6548\u3002<\/p>\n<\/section>\n

\n
\n
<\/section>\n
\n

\u6297IL-6\u6cbb\u7597<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/p>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u5728 ABMR \u4e2d\uff0cIL-6\u53ef\u4ee5 \u4fc3\u8fdbB\u7ec6\u80de\u53d1\u80b2\u548c\u6210\u719f\u4e3a\u6d46\u7ec6\u80de\uff0c\u4ea7\u751f\u9776\u5411\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u7269\u7684DSA\u3002<\/p>\n

\u5176\u81f4\u75c5\u4f5c\u7528\u6765\u6e90\u4e8e\u4ee5\u4e0b\u4e00\u4e9b\u8bc1\u636e\uff1a\uff081\uff09\u5728\u4e00\u4e2a\u975e\u5bf9\u7167\u7684\u80be\u79fb\u690d\u53d7\u4f53\u961f\u5217\u7814\u7a76\u4e2d\uff0c\u96be\u6cbb\u6027\u6162\u6027\u6d3b\u52a8\u6027 ABMR \u60a3\u8005\u6bcf\u6708\u8f93\u6ce8\u6258\u73e0\u5355\u6297 (TCZ-anti-IL-6R mAb) \u964d\u4f4e\u4e86 DSA \u548c\u5fae\u8840\u7ba1\u708e\u75c7\uff0c\u5e76\u7a33\u5b9a\u4e86eGFR\uff1b(2) \u6bcf\u6708 IVIg + TCZ \u8131\u654f\u6cbb\u7597 6 \u4e2a\u6708\uff0c\u80be\u79fb\u690d\u7387\u4e3a 50%\u3002\u603b\u4e4b\uff0c\u5728\u79fb\u690d\u524d\u548c\u79fb\u690d\u540e\u8fdb\u884c\u6297IL-6\u6cbb\u7597\u964d\u4f4e\u4e86 DSA \uff0c\u9884\u9632\u4e86ABMR\u7684\u53d1\u751f\u3002<\/p>\n

\u76ee\u524dTCZ 3 \u671f\u8bd5\u9a8c\u5c1a\u672a\u8fdb\u884c\uff0c\u4f46FDA \u65b0\u836f clazakizumab (Claza-anti-IL6 mAb) \u6b63\u5728\u6162\u6027\u6d3b\u52a8\u6027 ABMR \u60a3\u8005\u4e2d\u8fdb\u884c\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3 3 \u671f\u8bd5\u9a8c\u3002<\/p>\n


<\/p>\n<\/section>\n

\n
\n
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\u6211\u4eec\u8fd8\u9700\u63a2\u7d22\u4ec0\u4e48\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
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HLA \u4e0e\u975e HLA \u6297\u4f53\u7684\u76f8\u5bf9\u91cd\u8981\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/p>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8ba4\u4e3a\uff0c\u975e HLA \u9057\u4f20\u9519\u914d\u4e0e\u79fb\u690d\u7269\u4e22\u5931\u76f8\u5173\uff0c\u4e0e HLA \u9519\u914d\u65e0\u5173\u3002\u9664\u4e86\u68c0\u6d4b\u975e HLA \u6297\u4f53\u7684\u80fd\u529b\uff0c\u8fd8\u6709\u8bb8\u591a\u95ee\u9898\u4ecd\u7136\u5b58\u5728\uff1a\u975e HLA ABMR \u7684\u5b58\u5728\u7a0b\u5ea6\u5982\u4f55\uff1f\u975e HLA ABMR \u7684\u9884\u540e\u7ed3\u5c40\u662f\u4ec0\u4e48\uff1fSenev \u7b49\u7684\u8bba\u6587\u63d0\u793a\uff0c\u65e9\u671f\u975e HLA ABMR \u7684\u7ed3\u5c40\u4e0e\u65e0 ABMR \u7684\u80be\u79fb\u690d\u53d7\u8005\u76f8\u4f3c\u3002\u975e HLA ABMR \u7684\u6700\u4f73\u6cbb\u7597\u65b9\u6cd5\u662f\u4ec0\u4e48\uff0c\u5bf9\u201c\u6807\u51c6\u6cbb\u7597\u201d\u7684\u53cd\u5e94\u662f\u5426\u4f18\u4e8e\u6216\u5dee\u4e8e HLA DSA ABMR\uff1f\u663e\u7136\uff0c\u5173\u4e8e\u975e HLA \u76f8\u5173 ABMR \u8fd8\u6709\u5f88\u591a\u9700\u8981\u7814\u7a76\u7684\u5730\u65b9\u3002<\/p>\n<\/section>\n

\n
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TCMR \u4e0e ABMR \u7684\u76f8\u5bf9\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/p>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u901a\u5e38\uff0c\u665a\u671f\u6d3b\u52a8\u6027\u548c\u6162\u6027\u6d3b\u52a8\u6027 ABMR\u88ab\u8ba4\u4e3a\u662fTCMR\/ABMR \u6df7\u5408\u8868\u578b\uff0c\u7531\u6b64\u4ea7\u751f\u4e86\u4e00\u4e2a\u95ee\u9898\uff0c \u5373TCMR\u5728\u5bfc\u81f4\u79fb\u690d\u7269\u4e22\u5931\u4e2d\u6240\u8d77\u4f5c\u7528\u7684\u95ee\u9898\u3002\u4ec5\u9776\u5411 DSA\u3001\u6d46\u7ec6\u80de\u548c B \u7ec6\u80de\u662f\u5426\u8db3\u591f\uff1f\u662f\u5426\u8fd8\u9700\u8981\u8003\u8651 \u6cbb\u7597TCMR\u7684\u65b0\u65b9\u6cd5\uff1f\u5c3d\u7ba1 2017 \u5e74 Banff \u5de5\u4f5c\u7ec4\u5df2\u7ecf\u8ba4\u8bc6\u5230\u6162\u6027\u6d3b\u52a8\u6027 TCMR \u662f\u5bfc\u81f4\u79fb\u690d\u7269\u4e22\u5931\u7684\u539f\u56e0\uff0c\u4f46\u5c1a\u4e0d\u6e05\u695a\u5f53\u524d\u7684 TCMR \u6cbb\u7597\u65b9\u6cd5\u5728\u79fb\u690d\u665a\u671f\u662f\u5426\u8db3\u591f\u6709\u6548\u3002\u65b0\u7b56\u7565\uff08\u5982\u6297 IL6\/IL-6R \u6cbb\u7597\uff09\u5177\u6709\u8c03\u8282 B \u7ec6\u80de\u3001\u6d46\u7ec6\u80de\u548c T \u7ec6\u80de\u7684\u80fd\u529b\uff0c\u4e5f\u8bb8\u4f1a\u6709\u66f4\u4f18\u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n<\/section>\n

\n
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\n

CDC vs \u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027 (ADCC) \u6548\u5e94\u901a\u8def\u7684\u76f8\u5bf9\u91cd\u8981\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/p>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u9664\u4e86\u9776\u5411\u6297\u4f53\u7684\u4ea7\u751f\u5916\uff0c\u8fd8\u8981\u963b\u65ad\u4e0e IgG \u4ecb\u5bfc\u7684 C1q \u7ed3\u5408\u76f8\u5173\u7684 CDC \u6548\u5e94\u901a\u8def\u3002\u7136\u800c\uff0c\u4e0e IgG Fc\u03b3R (Fc\u03b3R) \u4ecb\u5bfc\u76f8\u5173\u7684 ADCC \u53ef\u80fd\u5728 ABMR \u4e2d\u540c\u6837\u53d1\u6325\u4f5c\u7528\uff0c\u56e0\u4e3a NK \u7ec6\u80de\u57fa\u56e0\u8f6c\u5f55\u589e\u52a0\uff0cMVI\uff08\u5fae\u8840\u7ba1\u708e\u75c7\uff09\u663e\u793a\u8868\u8fbe Fc\u03b3R \u7684 NK \u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u589e\u52a0\uff08\u56fe 2\uff09\u3002\u652f\u6301 DSA Fc\u03b3R \u4ecb\u5bfc\u7684 MVI \u5728 ABMR \u4e2d\u4f5c\u7528\u7684\u8bc1\u636e\u6765\u81ea\u6700\u8fd1 Fc\u03b3RIII \u57fa\u56e0\u591a\u6001\u6027\u7684 SNP \u5206\u6790\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u5c3d\u7ba1\u672a\u89c2\u5bdf\u5230\u80be\u529f\u80fd\u5dee\u5f02\uff0c\u4f46Fc\u03b3RIIIA \u9ad8\u4eb2\u548c\u529b\u53d8\u5f02\u4f53\u7eaf\u5408\u5b50\u4e2a\u4f53\u5177\u6709\u66f4\u591a\u7684 MVI \u548c\u66f4\u9ad8\u7684 ABMR \u8d8b\u52bf\u3002<\/p>\n

\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u975e\u8865\u4f53\u4ecb\u5bfc\u7684\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u7269\u635f\u4f24\u53ef\u80fd\u5728 ABMR \u76f8\u5173\u79fb\u690d\u7269\u4e22\u5931\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u9776\u5411 ABMR Fc\u03b3R \u4ecb\u5bfc\u7684 MVI \u6216\u4e0e MVI \u76f8\u5173\u7684\u7ec6\u80de\uff08\u5373 NK \u7ec6\u80de\u548c\/\u6216\u5de8\u566c\u7ec6\u80de\uff09\u7684\u7b56\u7565\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n


<\/p>\n<\/section>\n

\n
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\u63a8\u79fb\u541b\u63d2\u8bdd<\/p>\n<\/section>\n

\n
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\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0cABMR\u76f8\u5173\u9886\u57df\u5f00\u5c55\u4e86\u5927\u91cf\u7814\u7a76\uff0c\u4f46\u5728\u6cbb\u7597\u7b56\u7565\u65b9\u9762\u4f9d\u7136\u8fdb\u5c55\u751a\u5fae\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u665a\u671f\u6d3b\u52a8\u6027\u548c\u6162\u6027\u6d3b\u52a8\u6027ABMR\u3002\u76ee\u524d\u7684\u9996\u8981\u7b56\u7565\u662f\u901a\u8fc7\u6700\u4f73\u57fa\u7ebf\u514d\u75ab\u6291\u5236\u8fdb\u884c\u9884\u9632\uff0c\u7ef4\u6301\u8db3\u591f\u7684CNI\u66b4\u9732\u662f\u9884\u9632\u7684\u5173\u952e\u7b56\u7565\uff0c\u800c\u5171\u523a\u6fc0\u963b\u65ad\u6216\u8bb8\u53ef\u4ee5\u6210\u4e3a\u65b0\u7684\u975eCNI\u9884\u9632\u7b56\u7565\u3002\u4ece\u6cbb\u7597\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u8865\u4f53\u6291\u5236\u5242\u548cIL-6 \/ IL-6R\u963b\u65ad\u7684\u4e00\u4e9b\u7814\u7a76\u6570\u636e\u8868\u73b0\u51fa\u4e86\u5f88\u5927\u7684\u6f5c\u529b\u3002\u603b\u4e4b\uff0c\u8bb8\u591a\u95ee\u9898\u4ecd\u672a\u5f97\u5230\u89e3\u7b54\uff0c\u9884\u9632\u548c\u6cbb\u7597ABMR\u7684\u7814\u7a76\u524d\u666f\u4f9d\u7136\u5e7f\u9614\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

Reference:<\/span><\/p>\n

Am J Transplant. 2020 Jun;20 Suppl 4:12\u201322.<\/span><\/p>\n

DOI: 10.1111\/ajt.15859<\/span><\/p>\n

PMID:32538535<\/span><\/p>\n<\/section>\n

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\u6587\u7ae0\u8f6c\u8f7d\u81ea\uff1a\u4f18\u533bOnline\u5fae\u4fe1\u53f7<\/span><\/p>\n


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Scan the code to follow<\/section>\n
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