{"id":3194,"date":"2022-01-27T12:00:00","date_gmt":"2022-01-27T04:00:00","guid":{"rendered":"https:\/\/transnovo.com\/news\/%e6%9c%ba%e6%a2%b0%e7%81%8c%e6%b3%a8%e6%94%b9%e5%96%84%e5%bf%83%e8%82%8c%e4%bb%a3%e8%b0%a2%e5%92%8c%e5%8a%9f%e8%83%bd%ef%bc%8c%e9%99%8d%e4%bd%8e%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9\/"},"modified":"2022-01-27T12:00:00","modified_gmt":"2022-01-27T04:00:00","slug":"%e6%9c%ba%e6%a2%b0%e7%81%8c%e6%b3%a8%e6%94%b9%e5%96%84%e5%bf%83%e8%82%8c%e4%bb%a3%e8%b0%a2%e5%92%8c%e5%8a%9f%e8%83%bd%ef%bc%8c%e9%99%8d%e4%bd%8e%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/%e6%9c%ba%e6%a2%b0%e7%81%8c%e6%b3%a8%e6%94%b9%e5%96%84%e5%bf%83%e8%82%8c%e4%bb%a3%e8%b0%a2%e5%92%8c%e5%8a%9f%e8%83%bd%ef%bc%8c%e9%99%8d%e4%bd%8e%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9\/","title":{"rendered":"Mechanical perfusion improves myocardial metabolism and function and reduces the risk of death"},"content":{"rendered":"
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Click on the blue word to follow us<\/strong><\/p>\n<\/section>\n<\/section>\n

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Preface<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1Nature\u5b50\u520a\u53d1\u8868\u7684\u6587\u7ae0\u8868\u660e\u5fc3\u810f\u7ec6\u80de\u901a\u8fc7\u7ec6\u80de\u5185\u79bb\u5b50\u6c34\u5e73\u7684\u53d8\u5316\u6765\u8c03\u8282\u663c\u591c\u8282\u5f8b\uff0c\u5f53\u5fc3\u810f\u79bb\u5b50\u6c34\u5e73\u5931\u8c03\u65f6\u4f1a\u6253\u4e71\u5fc3\u810f\u663c\u591c\u8282\u5f8b\uff0c\u5bfc\u81f4\u5fc3\u810f\u731d\u6b7b\u4e0d\u826f\u4e8b\u4ef6\u98ce\u9669\u7684\u589e\u52a0\u3002<\/p>\n


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\u673a\u68b0\u704c\u6ce8\u4f5c\u4e3a\u5668\u5b98\u79fb\u690d\u91cd\u8981\u7684\u4fdd\u5b58\u65b9\u5f0f\uff0c\u53ef\u63d0\u4f9b\u6c27\u53ca\u8425\u517b\u7269\u8d28\uff0c\u6539\u5584\u5fc3\u810f\u4ee3\u8c22\u4e0e\u5fc3\u810f\u6536\u7f29\u529f\u80fd\uff0c\u7f29\u77ed\u7f3a\u8840\u65f6\u95f4\uff0c\u964d\u4f4e\u6b7b\u4ea1\u98ce\u9669\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u82f1\u56fd\u5251\u6865MRC\u5206\u5b50\u751f\u7269\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u56e2\u961f\u5728 Nature \u5b50\u520a\u53d1\u8868\u7684\u6587\u7ae0\u8868\u660e\uff0c\u94a0\u79bb\u5b50\u3001\u94be\u79bb\u5b50\u548c\u6c2f\u79bb\u5b50\u901a\u8fc7SLC12A\u5bb6\u65cf\u534f\u540c\u8f6c\u8fd0\u86cb\u767d\u7684\u7535\u4e2d\u6027\u4e3b\u52a8\u8f6c\u8fd0\uff0c\u5f71\u54cd\u548c\u8c03\u8282\u663c\u591c\u8282\u5f8b<\/span><\/strong>.<\/p>\n


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\u5fc3\u808c\u7ec6\u80de\u901a\u8fc7\u94a0\u3001\u94be\u3001\u6c2f\u79bb\u5b50\u6c34\u5e73\u53d8\u5316\u53ca\u632f\u5e45\u53d8\u5316\u6765\u8c03\u8282\u663c\u591c\u8282\u5f8b\u53ca\u5fc3\u7387\u3002\u5176\u4e2d\uff0c\u53ef\u6eb6\u6027\u86cb\u767d\u8d28\u7684\u8282\u5f8b\u5f71\u54cd\u79bb\u5b50\u7a33\u6001\uff0c\u5bf9\u5fc3\u808c\u7ec6\u80de\u7684\u751f\u7406\u5b66\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002\u5f53\u5fc3\u810f\u79bb\u5b50\u6216\u86cb\u767d\u8d28\u8282\u5f8b\u7684\u5931\u8c03\u4f7f\u5fc3\u810f\u4e0d\u80fd\u6ee1\u8db3\u589e\u52a0\u7684\u8f93\u51fa\u91cf\u9700\u6c42\u65f6\uff0c\u4f1a\u5bfc\u81f4\u4e0d\u826f\u4e8b\u4ef6\u5982\u5fc3\u810f\u731d\u6b7b\u7684\u98ce\u9669\u589e\u52a0<\/span><\/strong>.<\/p>\n<\/section>\n

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\u6709\u7814\u7a76\u663e\u793a\u5de5\u4f5c\u65e524:00\u4ee5\u540e\u5165\u7761\uff0c\u5fc3\u6897\u98ce\u9669\u4f1a\u589e\u52a062.8%\uff0c\u800c\u572822\uff1a01-23:00\u5c31\u5bdd\u7684\u4eba\u5fc3\u6897\u98ce\u9669\u6700\u4f4e2<\/sup>\u3002\u5176\u539f\u56e0\u662f\u5fc3\u810f\u53d7\u5230\u751f\u7269\u8282\u5f8b\u5f71\u54cd\uff0c\u6839\u636e\u663c\u591c\u8282\u5f8b\u5207\u6362\u4e0d\u540c\u7684\u901f\u7387\u3002\u5f53\u71ac\u591c\u65f6\uff0c\u5fc3\u7387\u6a21\u5f0f\u4f1a\u51fa\u73b0\u5f02\u5e38\uff0c\u731d\u6b7b\u98ce\u9669\u589e\u52a0\u3002<\/p>\n


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\u673a\u68b0\u704c\u6ce8\u4f5c\u4e3a\u5fc3\u810f\u79fb\u690d\u7684\u91cd\u8981\u4fdd\u5b58\u65b9\u5f0f\uff0c\u53ef\u63d0\u4f9b\u6c27\u53ca\u8425\u517b\u7269\u8d28\uff0c\u6539\u5584\u5fc3\u810f\u4ee3\u8c22\u4e0e\u5fc3\u810f\u6536\u7f29\u529f\u80fd\uff0c\u7f29\u77ed\u7f3a\u8840\u65f6\u95f4\uff0c\u964d\u4f4e\u6b7b\u4ea1\u98ce\u9669<\/span><\/strong>3,<\/sup>4<\/sup>.<\/p>\n


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\u4e00\u7bc7\u57fa\u7840\u7814\u7a76\u7ed3\u679c\u663e\u793a\u4e0e\u5e38\u89c4\u51b7\u4fdd\u5b58\u7ec4\u5fc3\u810f\u76f8\u6bd4\uff0c\u673a\u68b0\u704c\u6ce8\u7ec4\u7684\u5fc3\u7387\u548c\u5fc3\u810f\u6536\u7f29\u6307\u6570\u53caATP\u6c34\u5e73\u663e\u8457\u9ad8\u4e8e\u5e38\u89c4\u51b7\u4fdd\u5b58\u7ec4<\/span><\/strong>\uff08\u56fe1\uff0c\u56fe2\uff09\uff0c\u6709\u964d\u4f4e\u94be\u79bb\u5b50\u3001\u4e73\u9178\u8131\u6c22\u9176\uff08LDH\uff09\u3001\u808c\u9178\u6fc0\u9176\uff08CK\uff09\u548c\u808c\u9499\u86cb\u767dT\uff08TnT\uff09\u6c34\u5e73\u7684\u8d8b\u52bf\uff08\u56fe3\uff094<\/sup>.<\/p>\n


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\u53e6\u4e00\u7bc7\u6301\u7eed\u6c27\u5408\u8840\u704c\u6ce8\u4fdd\u5b58\u5fc3\u810f\u5b9e\u9a8c\u7814\u7a76\u4e5f\u663e\u793a\uff0c\u76f8\u6bd4\u4e8e\u4f4e\u6e29\u6d78\u6ce1\u4fdd\u5b58\u7ec4\uff0c\u6301\u7eed\u6c27\u5408\u8840\u704c\u6ce8\u4fdd\u5b58\u7ec4\u732a\u7684\u5fc3\u808c\u7ec6\u80de\u8d85\u5fae\u7ed3\u6784\u4fdd\u5b58\u826f\u597d<\/span><\/strong>\uff0c\u5fc3\u808c\u7ec6\u80de\u5185\u9ad8\u80fd\u78f7\u9178\u5316\u5408\u7269ATP\u542b\u91cf\u8f83\u9ad85<\/sup>.<\/p>\n


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\u53e6\u4e00\u7bc7\u7814\u7a76\u6bd4\u8f83\u4e0d\u540c\u704c\u6ce8\u6d41\u91cf\u4e0b\u5de6\u5ba4\u6536\u7f29\u538b\u3001\u8212\u5f20\u538b\u3001\u5fc3\u808c\u8017\u6c27\u91cf\u3001\u5fc3\u7387\uff0c\u6765\u8bc4\u4ef7\u79bb\u4f53\u5fc3\u810f\u529f\u80fd\uff0c\u7ed3\u679c\u663e\u793a\u4f4e\u6d41\u91cf\u4e0e\u9ad8\u6d41\u91cf\u65f6\u7684\u5fc3\u7387\u3001\u5de6\u5ba4\u6536\u7f29\u538b\u3001\u8212\u5f20\u538b\u7684\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u5728\u4f4e\u6d41\u91cf\u6e29\u8840\u6301\u7eed\u704c\u6ce8\u4fdd\u5b58\u4e0b\uff0c\u79bb\u4f53\u5fc3\u810f\u5fc3\u808c\u672a\u53d1\u751f\u660e\u663e\u6c34\u80bf\uff0c\u51a0\u8109\u5185\u76ae\u7ec6\u80de\u672a\u660e\u663e\u53d7\u635f\uff0c\u5fc3\u529f\u80fd\u826f\u597d6<\/sup>.<\/p>\n


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\u56fe1.\u4e0d\u540c\u7ec4\u5fc3\u7387\u3001\u5fc3\u808c\u6536\u7f29\u6307\u6570\u6bd4\u8f83<\/span><\/p>\n<\/section>\n

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\u6ce8\uff1a\u4e09\u7ec4\u5bf9\u6bd4\uff1a\u4e3a\u65b0\u9c9c\u5fc3\u810f\u5bf9\u7167\u7ec4\uff08Fresh\uff09\u3001\u5e38\u89c4\u51b7\u4fdd\u5b58\u7ec4\uff08WI\uff09\u548c\u673a\u68b0\u704c\u6ce8\u5904\u7406\u7684\u7f3a\u8840\u7ec4\uff08WI+Recond\uff09\u3002A\u4e3a\u5e73\u5747\u5fc3\u7387\uff1bB\u4e3a\u5e73\u5747\u5fc3\u808c\u6536\u7f29\u6307\u6570\uff1bC\u4e3a\u6700\u5927\u5fc3\u7387\uff1bD\u4e3a\u7b49\u5bb9\u6536\u7f29\u671f\u6307\u6807\u3002<\/span><\/p>\n<\/section>\n

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\u56fe2.\u4e0d\u540c\u7ec4ATP\u6c34\u5e73\u7684\u6bd4\u8f83<\/p>\n<\/section>\n

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\u56fe3.\u4e0d\u540c\u7ec4\u94be\u79bb\u5b50\u3001LDH\u3001TnT\u3001CK\u6c34\u5e73\u7684\u6bd4\u8f83<\/p>\n<\/section>\n

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\u673a\u68b0\u704c\u6ce8\u5728\u5fc3\u810f\u79fb\u690d\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u673a\u68b0\u704c\u6ce8\u8f83\u5e38\u89c4\u51b7\u85cf\u6539\u5584\u5fc3\u810f\u79fb\u690d\u7684\u7ed3\u5c40\uff0c\u673a\u68b0\u704c\u6ce8\u663e\u8457\u7f29\u77ed\u7f3a\u8840\u65f6\u95f4\uff08132min vs 225min\uff0cP\uff1c0.001\uff09\u3001\u663e\u8457\u964d\u4f4e\u7f3a\u8840\u65f6\u95f4\uff1e4h\u7684\u6982\u7387\uff080 vs 38%\uff0cP\uff1c0.01\uff09\uff0c\u6709\u964d\u4f4e30\u5929\u6b7b\u4ea1\u7387\u7684\u8d8b\u52bf\uff080 vs 13%\uff09\uff0c\u663e\u8457\u964d\u4f4e\u79fb\u690d\u7269\u5931\u8d25\uff08PGD\uff09\u7684\u6982\u7387\uff087% vs 42%\uff0cP=0.03\uff09\uff0c\u6709\u63d0\u9ad81\u5e74\u751f\u5b58\u7387\u7684\u8d8b\u52bf\uff0884% vs 79%\uff09\uff08\u56fe4\uff097<\/sup>.<\/p>\n


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\u53e61\u7bc7\u4e34\u5e8a\u7814\u7a76\u4e5f\u663e\u793a\uff0c\u4e0e\u5e38\u89c4\u51b7\u85cf\u76f8\u6bd4\uff0c\u673a\u68b0\u704c\u6ce8\u663e\u8457\u7f29\u77ed\u7f3a\u8840\u65f6\u95f4\uff08P =\uff1c0.0001\uff098<\/sup>.<\/p>\n


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\u56fe4.\u673a\u68b0\u704c\u6ce8\u4e0e\u5e38\u89c4\u51b7\u85cf\u7ec4\u5fc3\u810f\u79fb\u690d\u540e\u7684\u6307\u6807\u6bd4\u8f83<\/span><\/p>\n<\/section>\n

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\u5fc3\u810f\u663c\u591c\u8282\u5f8b\u53d7\u751f\u7269\u949f\u3001\u79bb\u5b50\u6c34\u5e73\u53d8\u5316\u7b49\u5f71\u54cd\uff0c\u5f53\u71ac\u591c\u3001\u79bb\u5b50\u6c34\u5e73\u8282\u5f8b\u5931\u8c03\u65f6\uff0c\u4f1a\u589e\u52a0\u731d\u6b7b\u7684\u98ce\u9669\u3002<\/p>\n


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\u673a\u68b0\u704c\u6ce8\u4f5c\u4e3a\u5fc3\u810f\u79fb\u690d\u91cd\u8981\u7684\u4fdd\u5b58\u65b9\u5f0f\uff0c\u63d0\u4f9b\u6c27\u53ca\u8425\u517b\u7269\u8d28\uff0c\u6539\u5584\u5fc3\u808c\u4ee3\u8c22\u5982\u5f71\u54cd\u94be\u79bb\u5b50\u3001ATP\u7b49\u6c34\u5e73\uff0c\u63d0\u9ad8\u5fc3\u810f\u6536\u7f29\u529f\u80fd\uff0c\u964d\u4f4e\u6b7b\u4ea1\u98ce\u9669\u3002\u76ee\u524d\u867d\u65e0\u673a\u68b0\u704c\u6ce8\u964d\u4f4e\u731d\u6b7b\u7684\u76f4\u63a5\u8bc1\u636e\uff0c\u4f46\u5176\u5728\u57fa\u7840\u7814\u7a76\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u8868\u660e\u4e86\u673a\u68b0\u704c\u6ce8\u7684\u4f18\u52bf\u4e0e\u964d\u4f4e\u6b7b\u4ea1\u7684\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Reference:<\/p>\n

1.Stangherlin A,et al.Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology. Nat Commun. 2021 Oct 15;12(1):6035.<\/p>\n

2.Yajuan Fan,et al.Sleeping Late Increases the Risk of Myocardial Infarction in the Middle-Aged and Older Populations . Front Cardiovasc Med. 2021 Sep 24;8:709468.<\/p>\n

3.\u4ef2\u8087\u57fa, \u5218\u76db. \u4f9b\u5fc3\u673a\u68b0\u704c\u6ce8\u4e0e\u4fdd\u5b58\u7814\u7a76\u8fdb\u5c55[J]. \u5668\u5b98\u79fb\u690d, 2017, 8(3):5:215-219.<\/p>\n

4.Herman Tolboom\uff0cet al.Recovery of donor hearts after circulatory death with normothermic extracorporeal machine perfusion. Eur J Cardiothorac Surg . 2015 Jan;47(1):173-9.<\/p>\n

5.\u674e\u52c7\u7537. \u6301\u7eed\u6c27\u5408\u8840\u704c\u6ce8\u4fdd\u5b58\u4f9b\u4f53\u5fc3\u810f\u5b9e\u9a8c\u7814\u7a76[D]. \u5170\u5dde\u5927\u5b66, 2016.<\/p>\n

6.\u5218\u6d0b. \u79bb\u4f53\u732a\u5fc3\u810f\u4fdd\u5b58\u53ca\u529f\u80fd\u8bc4\u4ef7\u7684\u8fdb\u5c55\u6027\u7814\u7a76[D]. \u90d1\u5dde\u5927\u5b66, 2014.<\/p>\n

7.Sandro Sponga,et al.Heart transplant outcomes in patients with mechanical circulatory support: cold storage versus normothermic perfusion organ preservation. Interact Cardiovasc Thorac Surg  . 2021;32(3):476-482.<\/p>\n

8.Abbas Ardehali.et al. Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial. Lancet.2015 Jun 27;385(9987):2577-84.<\/p>\n


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Scan the code to follow us<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Micro Signal\uff5cTx New Solution<\/p>\n

Jianfeng Medicine, focus on transplant industry<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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