{"id":1894,"date":"2022-10-25T15:00:16","date_gmt":"2022-10-25T07:00:16","guid":{"rendered":"https:\/\/transnovo.com\/news\/gcfdna%e5%bc%a5%e8%a1%a5dsa%e7%9f%ad%e6%9d%bf%ef%bc%8c%e8%81%94%e5%90%88%e5%ba%94%e7%94%a8%e9%a2%84%e8%ad%a6amr\/"},"modified":"2022-10-25T15:00:16","modified_gmt":"2022-10-25T07:00:16","slug":"gcfdna%e5%bc%a5%e8%a1%a5dsa%e7%9f%ad%e6%9d%bf%ef%bc%8c%e8%81%94%e5%90%88%e5%ba%94%e7%94%a8%e9%a2%84%e8%ad%a6amr","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/gcfdna%e5%bc%a5%e8%a1%a5dsa%e7%9f%ad%e6%9d%bf%ef%bc%8c%e8%81%94%e5%90%88%e5%ba%94%e7%94%a8%e9%a2%84%e8%ad%a6amr\/","title":{"rendered":"GcfDNA bridges DSA shortcomings with joint application of early warning AMR"},"content":{"rendered":"
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Click on the blue word to follow us<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u672c\u4e16\u7eaa\u521d\u4ee5\u6765\uff0c\u5728\u80be\u79fb\u690d\u9886\u57df\u6297\u4f53\u4ecb\u5bfc\u6392\u65a5\u53cd\u5e94 \uff08antibody\u2011mediated rejection\uff0cAMR\uff09\u65e5\u76ca\u53d7\u5230\u91cd\u89c6\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u663e\u793aAMR\u662f\u5f71\u54cd\u79fb\u690d\u80be\u957f\u671f\u5b58\u6d3b\u7684\u6700\u5927\u969c\u788d\uff0c\u7ea660%\u7684\u79fb\u690d\u80be\u5931\u529f\u4e0e\u5176\u6709\u5173\uff3b1\uff3d<\/sup>.<\/p>\n


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AMR\u8bca\u65ad\u73b0\u72b6\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524dAMR\u8bca\u65ad\u91d1\u6807\u51c6\u662f\u75c5\u7406\u6d3b\u68c0\uff0c\u4f46\u6d3b\u68c0\u5c5e\u4e8e\u6709\u521b\u64cd\u4f5c\uff0c\u4e14\u7a7f\u523a\u65f6\u673a\u7684\u628a\u63e1\u3001\u75c5\u7406\u5f02\u8d28\u6027\u53ca\u9605\u7247\u4e13\u5bb6\u7684\u7ecf\u9a8c\u90fd\u4f1a\u5f71\u54cd\u7ed3\u679c\u7684\u51c6\u786e\u6027\u3002<\/p>\n


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DSA\u662f\u5bfc\u81f4AMR\u7684\u4e3b\u8981\u75c5\u56e0\uff0cDSA\u5206\u4e3a\u9884\u5b58DSA\uff08preformed DSA\uff0cpfDSA\uff09\u548c\u65b0\u751fDSA\uff08de novo DSA\uff0cdnDSA\uff09\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5bf9\u4e8e\u6162\u6027\u6d3b\u52a8\u6027AMR\u7684\u6cbb\u7597\u5c1a\u672a\u5f62\u6210\u7edf\u4e00\u65b9\u6848\u3002\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0cdn DSA\u5f15\u8d77\u7684AMR\u5728\u8bca\u65ad\u540e8\u5e74\u79fb\u690d\u80be\u751f\u5b58\u7387\u4ec5\u4e3a34%\uff3b2\uff3d<\/sup>.\u65e9\u671f\u53d1\u73b0DSA\u610f\u5473\u7740\u80fd\u591f\u65e9\u671f\u53d1\u73b0\u79fb\u690d\u80be\u53d1\u751f\u6392\u65a5\u53cd\u5e94\uff0c<\/span><\/strong>\u53ca\u65e9\u5730\u8fdb\u884c\u5e72\u9884\u6cbb\u7597\uff0c\u5bf9\u4e8e\u5ef6\u7f13\u8fd9\u79cd\u6162\u6027\u75c5\u53d8\u7684\u8fdb\u5c55\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/span><\/strong><\/span><\/strong><\/p>\n


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DSA\u68c0\u6d4b\u77ed\u677f\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u4e34\u5e8a\u4e0a\u68c0\u6d4bDSA\u7684\u5e38\u7528\u65b9\u6cd5\u662f\u5355\u6297\u539f\u5fae\u73e0\u6cd5\uff08single antigen beads\uff0cSAB\uff09\u3002SAB\u654f\u611f\u6027\u9ad8\uff0c\u53ef\u4ee5\u660e\u786e\u6297\u4f53\u79cd\u7c7b\u3002\u4f46\u662f\u53d7\u8bd5\u5242\u643a\u5e26\u6297\u539f\u79cd\u7c7b\u6570\u76ee\u7684\u9650\u5236\u548c\u6297\u539f\u5236\u5907\u8fc7\u7a0b\u4e2d\u53d8\u6027\u7b49\u56e0\u7d20\u7684\u5f71\u54cd\uff0cDSA\u5728\u68c0\u6d4b\u65b9\u9762\u5b58\u5728\u6f0f\u68c0\u548c\u5047\u9633\u6027\u7684\u60c5\u51b5\u3002<\/span><\/strong><\/p>\n


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\u5728\u4e34\u5e8a\u8bca\u65ad\u65b9\u9762\uff0cDSA\u68c0\u6d4b\u6ca1\u6709\u7edf\u4e00\u7684\u9633\u6027\u9608\u503c\u6807\u51c6\uff0c<\/span><\/strong>\u6bcf\u4e2a\u79fb\u690d\u4e2d\u5fc3\u7684\u5224\u65ad\u6807\u51c6\u90fd\u4e0d\u4e00\u6837\u3002\u540c\u65f6\uff0cDSA\u9633\u6027\u5230AMR\u75c5\u7406\u635f\u4f24\u9700\u8981\u4e00\u5b9a\u7684\u65f6\u95f4\uff0c\u800c\u4e14DSA\u9633\u6027\u4e5f\u4e0d\u4e00\u5b9a\u5c31\u9020\u6210AMR\u75c5\u7406\u635f\u4f24\u3002\u56e0\u6b64\uff0cDSA\u68c0\u6d4b\u5728\u9884\u8b66AMR\u65b9\u9762\u8fd8\u5b58\u5728\u4e0d\u8db3\u548c\u77ed\u677f\u3002<\/p>\n


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GcfDNA\u8865DSA\u68c0\u6d4b\u77ed\u677f:<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u79fb\u690d\u5668\u5b98\u53d1\u751f\u635f\u4f24\u65f6\u964d\u89e3\u7684DNA\u7247\u6bb5\u4f1a\u91ca\u653e\u5230\u8840\u6d46\u4e2d\uff0c\u79f0\u4e3a\u79fb\u690d\u7269\u6765\u6e90\u7ec6\u80de\u6e38\u79bbDNA\uff08Graft-derived Cell-free DNA\uff0cGcfDNA\uff09\u3002GcfDNA\u6d53\u5ea6\u4e0e\u79fb\u690d\u80be\u635f\u4f24\u5bc6\u5207\u76f8\u5173\uff0c\u662f\u5668\u5b98\u65e9\u671f\u635f\u4f24\u7684\u654f\u611f\u6807\u5fd7\u7269\u3002<\/p>\n


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Bu L\u7b49\u4eba\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u5171\u7eb3\u5165\u4e861092 \u540d\u80be\u79fb\u690d\u53d7\u8005\uff0c\u968f\u8bbf\u65f6\u95f43\u5e74\uff0c\u5bf9\u5176\u4e2d\u7684961\u540d\u60a3\u8005\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u53d1\u73b0GcfDNA\u5347\u9ad8\u4e0e\u4e34\u5e8a\/\u4e9a\u4e34\u5e8a\u6392\u65a5\u53cd\u5e94\u7684\u53d1\u751f\u663e\u8457\u76f8\u5173[3]<\/sup>\u3002\u4ee5\u4e0b\u4e24\u70b9\u662f\u8be5\u7814\u7a76\u7684\u90e8\u5206\u8be6\u7ec6\u5185\u5bb9\uff1a<\/p>\n


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1\u3001GcfDNA\u662f\u5668\u5b98\u635f\u4f24\u7684\u91cd\u8981\u65e9\u671f\u654f\u611f\u6807\u5fd7\u7269<\/strong><\/span><\/p>\n


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\u7814\u7a76\u5206\u6790\u4e86GcfDNA\u5728\u5224\u65ad\u80be\u810f\u635f\u4f24\u4e2d\u7684\u4e34\u5e8a\u4ef7\u503c\u3002\u7814\u7a76\u5c06\u80be\u810f\u635f\u4f24\u5b9a\u4e49\u4e3a\uff1a\u4ed6\u514b\u83ab\u53f8\u6d53\u5ea6\u6c34\u5e73\uff08<4ng\/ml \u6216 >12ng\/ml\uff09\u3001BK\u75c5\u6bd2\u8840\u75c7\u3001dnDSA\u9633\u6027\u3001\u5c3f\u8def\u611f\u67d3\u3001\u86cb\u767d\u5c3f\u3001\u51fa\u73b0\u79fb\u690d\u7269\u6392\u65a5\u6216\u590d\u53d1\u5c40\u7076\u6027\u8282\u6bb5\u6027\u80be\u5c0f\u7403\u786c\u5316\u3002<\/p>\n


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\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u5171467\u4f8b\u60a3\u8005\u51fa\u73b0\u80be\u635f\u4f24\uff0c\u800cGcfDNA\u5728\u635f\u4f24\u53d1\u751f\u524d30\u5929\u5373\u51fa\u73b0\u4e86\u5347\u9ad8\uff0c\u635f\u4f24\u7ec4\u548c\u975e\u635f\u4f24\u7ec4\u7684GcfDNA\u6c34\u5e73\u5b58\u5728\u660e\u663e\u5dee\u5f02\uff080.51% vs 0.21%\uff0cP<0.0001\uff09\uff08\u56fe1\uff09\u3002<\/p>\n<\/section>\n


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\u56fe1\uff1aGcfDNA\u4e0e\u808c\u9150\u5728\u80be\u635f\u4f24\u4e2d\u7684\u8bca\u65ad\u6027\u80fd\u6bd4\u8f83<\/span>
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2\u3001GcfDNA\u5347\u9ad8\u4f34\u968f\u7740dnDSA\u4ea7\u751f\u98ce\u9669\u589e\u52a0<\/span><\/strong>
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\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u5f53\u60a3\u8005GcfDNA>0.5%\uff0c\u5176\u672a\u6765\u51fa\u73b0dnDSA\u7684\u98ce\u9669\u5347\u9ad83\u500d\uff08HR 2.71\uff0cp=0.001\uff09\uff08\u56fe2\uff09\uff0c\u4e14GcfDNA\u5728dnDSA\u9633\u6027\u524d91\u5929\uff08\u56db\u5206\u4f4d\u6570\uff1a30-125\u5929\uff09\u5373\u53ef\u51fa\u73b0\u5347\u9ad8\u3002<\/p>\n<\/section>\n


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\u56fe2\uff1aGcfDNA\u4e0ednDSA\u53d1\u751f\u7387\u7684Cox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b<\/span>
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GcfDNA\u68c0\u6d4b\u5efa\u8bae\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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    \u5efa\u8bae\u672f\u540e1\u6708\u5185<\/span><\/strong>\u5b8c\u6210GcfDNA\u7684\u9996\u6b21\u68c0\u6d4b\uff0c\u4ee5\u786e\u5b9a\u57fa\u7ebfGcfDNA\u6c34\u5e73\u3002\u65e9\u671f\u8f83\u9ad8\u7684GcfDNA\u63d0\u793a\u60a3\u8005\u5b58\u5728\u53d1\u751f\u6025\u6027\u6392\u65a5\u53cd\u5e94\u7684\u98ce\u9669\u3002<\/p>\n


    <\/p>\n<\/li>\n

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    \u8c03\u6574\u514d\u75ab\u6291\u5236\u6cbb\u7597\u65b9\u6848\u671f\u95f4\u6ce8\u610f\u968f\u8bbfGcfDNA\u6c34\u5e73\uff0c\u53ca\u65e9\u53d1\u73b0\u56e0\u514d\u75ab\u6291\u5236\u4e0d\u8db3\u5bfc\u81f4\u7684\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n


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    \u672f\u540e\u957f\u671f\u968f\u8bbf\u8fc7\u7a0b\u4e2d\uff0c\u5b9a\u671f\u76d1\u6d4bGcfDNA\u4ee5\u8bc4\u4f30\u53d1\u751fdnDSA\u53ca\u79fb\u690d\u7269\u529f\u80fd\u635f\u4f24\u7684\u98ce\u9669\u3002\u6839\u636e\u53c2\u8003\u6587\u732e\uff0c\u8003\u8651\u5b9e\u9645\u60c5\u51b5\uff0c\u6211\u4eec\u5efa\u8bae\u5728\u672f\u540e1\u30013\u30016\u30019\u300112\u6708\u5404\u8fdb\u884c1\u6b21GcfDNA\u68c0\u6d4b\uff0c\u6b64\u540e\u6bcf\u5b63\u5ea6\u8fdb\u884c1\u6b21GcfDNA\u68c0\u6d4b[4]<\/sup>.<\/span><\/strong><\/p>\n<\/li>\n<\/ol>\n


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    Summary<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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    1\u3001AMR\u76ee\u524d\u8bca\u6cbb\u90fd\u9762\u4e34\u5f88\u591a\u56f0\u96be\uff1b<\/span><\/p>\n

    2\u3001DSA\u76d1\u6d4b\u5728AMR\u9884\u8b66\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\uff1b<\/p>\n

    3\u3001DSA\u68c0\u6d4b\u5b58\u5728\u77ed\u677f\uff0c\u540c\u65f6DSA\u4e34\u5e8a\u7ed3\u679c\u5224\u8bfb\u6807\u51c6\u4e0d\u4e00\uff0c\u4e34\u5e8a\u5e94\u7528\u5b58\u5728\u5c40\u9650\uff1b<\/p>\n

    4\u3001GcfDNA\u53ef\u53cd\u5e94\u79fb\u690d\u7269\u635f\u4f24\uff0c\u5f25\u8865DSA\u77ed\u677f\uff0c\u63d0\u9ad8AMR\u8bca\u65ad\u6027\u80fd\uff1b<\/p>\n

    5\u3001\u79fb\u690d\u60a3\u8005\u672f\u540e\u5efa\u8bae\u52a8\u6001\u76d1\u6d4bGcfDNA\uff0c\u5c24\u5176\u5728\u672f\u540e1\u5e74\u5185\u9700\u52a0\u5f3a\u76d1\u6d4b\u9891\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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    Reference:<\/span><\/p>\n

    \uff3b1\uff3d \u5d14\u745c, \u5f20\u96f7, \u5434\u5efa\u6c38 . \u80be\u79fb\u690d\u6297\u4f53\u4ecb\u5bfc\u6392\u65a5\u53cd\u5e94\u7684\u9884\u9632\u53ca\u8bca\u7597\u8981\u70b9[J]. \u4e2d\u534e\u533b\u5b66\u6742\u5fd7, 2022, 102(26): 2041-2044. DOI: 10.3760\/cma.j.cn112137-20220520-01117.<\/span><\/p>\n

    \uff3b2\uff3d\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u79fb\u690d\u6280\u672f\u5206\u4f1a, \u4e0a\u6d77\u5e02\u80be\u810f\u79fb\u690d\u8d28\u63a7\u4e2d\u5fc3\u4e13\u5bb6\u59d4\u5458\u4f1a . \u80be\u79fb\u690d\u540e\u671f\u6297\u4f53\u4ecb\u5bfc\u6392\u65a5\u53cd\u5e94\u9632\u6cbb\u4e13\u5bb6\u5171\u8bc6[J]. \u4e2d\u534e\u533b\u5b66\u6742\u5fd7, 2022, 102(26): 1973-1981. DOI: 10.3760\/cma.j. cn112137-20220129-00217.<\/span><\/p>\n

    \uff3b3\uff3dBu L, et al. Clinical outcomes from the Assessing Donor-derived cell-free DNA Monitoring Insights of kidney Allografts with Longitudinal surveillance (ADMIRAL) study. Kidney Int. 2022 Apr;101(4):793-803. doi: 10.1016\/j.kint.2021.11.034.<\/span><\/p>\n

    \uff3b4\uff3d Pai A, et al. Clinical Rationale for a Routine Testing Schedule Using Donor-Derived Cell-Free DNA After Kidney Transplantation. Ann Transplant. 2021 Jul 2;26:e932249. doi: 10.12659\/AOT.932249.<\/span><\/p>\n<\/section>\n<\/section>\n

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