{"id":1873,"date":"2022-11-14T15:30:48","date_gmt":"2022-11-14T07:30:48","guid":{"rendered":"https:\/\/transnovo.com\/news\/2022tts%e4%b9%8bgcfdna-%e6%8e%92%e6%96%a5%e9%a2%84%e8%ad%a6%e7%96%97%e6%95%88%e8%af%84%e4%bc%b0%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%91%e6%b5%8b%e5%88%a9%e5%99%a8\/"},"modified":"2022-11-14T15:30:48","modified_gmt":"2022-11-14T07:30:48","slug":"2022tts%e4%b9%8bgcfdna-%e6%8e%92%e6%96%a5%e9%a2%84%e8%ad%a6%e7%96%97%e6%95%88%e8%af%84%e4%bc%b0%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%91%e6%b5%8b%e5%88%a9%e5%99%a8","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/2022tts%e4%b9%8bgcfdna-%e6%8e%92%e6%96%a5%e9%a2%84%e8%ad%a6%e7%96%97%e6%95%88%e8%af%84%e4%bc%b0%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%91%e6%b5%8b%e5%88%a9%e5%99%a8\/","title":{"rendered":"2022TTS of GcfDNA - a clinical monitoring tool for rejection warning + efficacy assessment"},"content":{"rendered":"
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Click on the blue word to follow us<\/strong><\/p>\n<\/section>\n<\/section>\n

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Preface<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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GcfDNA\u4f5c\u4e3a\u4e00\u79cd\u65e0\u521b\u68c0\u6d4b\u9879\u76ee\uff0c\u5728\u79fb\u690d\u60a3\u8005\u672f\u540e\u968f\u8bbf\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n


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\u591a\u9879\u7814\u7a76\u8868\u660eGcfDNA\u4e0d\u4ec5\u80fd\u591f\u65e9\u671f\u9884\u8b66\u6392\u65a5\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u8fd8\u5177\u6709\u8bc4\u4f30\u6392\u65a5\u53cd\u5e94\u6cbb\u7597\u7597\u6548\u3001\u533a\u5206\u6392\u65a5\u53cd\u5e94\u7c7b\u578b\u7b49\u4f5c\u7528\u3002<\/span><\/strong><\/p>\n


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\u73b0\u5c062022\u5e74TTS\u4f1a\u8bae\u4e2dGcfDNA\u76f8\u5173\u6c47\u62a5\u8fdb\u884c\u603b\u7ed3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n


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GcfDNA\u9884\u6d4b\u60a3\u8005\u672f\u540e\u53d1\u751f\u6392\u65a5\u53cd\u5e94<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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Mantios\u7b49\u4eba[1]<\/sup>\u7eb3\u5165\u4e8632\u4f8b\u56e0\u5404\u79cd\u539f\u56e0\u8fdb\u884c\u672f\u540e\u80be\u6d3b\u68c0\u7684\u60a3\u8005\uff0c\u5728\u6d3b\u68c0\u65f6\u548c\u6cbb\u75974\u5468\u540e\u6d4b\u5b9aGcfDNA\u3002
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AR\u7ec4\u4e0e\u672a\u53d1\u751f\u6392\u5f02\u53cd\u5e94\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dGcfDNA\u5b58\u5728\u660e\u663e\u5dee\u5f02\uff0c\u5206\u522b\u4e3a0.94%\u548c0.24%\uff1b\u4e14ABMR\u548cTCMR\u7ec4\u60a3\u8005\u7684GcfDNA\u4e2d\u4f4d\u6c34\u5e73\u4ea6\u5b58\u5728\u663e\u8457\u5dee\u5f02(13% vs 0.52%)\u3002\u5f53\u5207\u70b9\u8bbe\u7f6e\u57280.5%\u65f6\uff0cGcfDNA\u8bca\u65adAR\u7684\u7075\u654f\u5ea6\u4e3a73.7%\uff0c\u7279\u5f02\u5ea692.3%\uff08\u56fe1\uff09\u3002<\/p>\n<\/section>\n


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\u56fe1.GcfDNA\u548c\u8840\u808c\u9150\u5bf9\u6d3b\u68c0\u8bc1\u5b9e\u7684AR\u7684\u8bca\u65ad\u6027\u80fd<\/span><\/p>\n


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Alejandra\u7b49\u4eba[2]<\/sup> \u5bf93\u5e74\u95f4\u5171695\u540d\u60a3\u8005\u76843157\u6b21GcfDNA\u68c0\u6d4b\u8fdb\u884c\u4e86\u56de\u987e\u6027\u7814\u7a76\u3002\u7ed3\u679c\u63d0\u793a\u518d\u79fb\u690d\u3001\u9ad8\u654f\u60a3\u8005\u3001\u65e9\u671f\u518d\u624b\u672f\u60a3\u8005\u7684\u672f\u540e1\u6708GcfDNA\u6c34\u5e73\u8f83\u9ad8\u3002\u672f\u540e1\u6708\u6d3b\u68c0\u9634\u6027\u548c\u9633\u6027\u7684\u79fb\u690d\u60a3\u8005GcfDNA\uff08%\uff09\u5206\u522b\u4e3a\uff080.49\u00b10.4\uff09\u548c\uff081.5\u00b11.8\uff09\u3002<\/p>\n


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\u5e73\u5747\u968f\u8bbf14\u4e2a\u6708\u663e\u793a\uff0c\u60a3\u8005\u672f\u540e1\u6708GcfDNA >1.0%\u65f6\uff0c\u968f\u540e\u7684AR\u53d1\u751f\u7387\u4e3a27%\uff1b\u60a3\u8005\u672f\u540e1\u6708GcfDNA\u22652.0%\uff0cAR\u53d1\u751f\u7387\u5347\u81f350%\u3002<\/p>\n


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\u8be5\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u672f\u540e1\u6708GcfDNA\uff1e1%\u7684\u60a3\u8005\u5b58\u5728\u66f4\u5927\u7684AR\u53d1\u751f\u98ce\u9669\uff0c\u9700\u5bf9\u8fd9\u90e8\u5206\u60a3\u8005\u8fdb\u884c\u66f4\u52a0\u5bc6\u5207\u7684\u4e34\u5e8a\u968f\u8bbf\u3002<\/span><\/strong><\/p>\n


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GcfDNA\u9884\u6d4b\u60a3\u8005\u672f\u540e\u53d1\u751f\u6392\u65a5\u53cd\u5e94<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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Gohh\u7b49\u4eba[3]<\/sup>\u901a\u8fc7\u6d3b\u68c0\u786e\u8ba442\u4f8b\u60a3\u8005\u5b58\u5728AR\uff0c\u540c\u65f6\u8fdb\u884c\u4e86GcfDNA\u68c0\u6d4b\u3002\u968f\u540e\u5bf9\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\uff0c\u5e76\u968f\u8bbf60-150\u5929\u3002<\/p>\n


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\u7ed3\u679c\u63d0\u793a\u6cbb\u7597\u540eGcfDNA\u6c34\u5e73\u51fa\u73b0\u660e\u663e\u964d\u4f4e\uff0c\u75311.11%\u964d\u81f30.35%\uff0c\u800c\u540c\u671feGFR\u5e76\u65e0\u660e\u663e\u53d8\u5316\uff08\u56fe2a\uff09\u3002\u5355\u72ec\u5206\u6790ABMR\/\u6df7\u5408\u6392\u65a5\u53cd\u5e94\u53caTCMR\u4e9a\u7ec4\u65f6\uff0c\u4e0a\u8ff0\u7ed3\u8bba\u4f9d\u7136\u6210\u7acb(\u56fe2b-c)\u3002<\/p>\n<\/section>\n


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\u56fe2a-c\uff1aAR\u60a3\u8005\u6cbb\u7597\u524d\u540eGcfDNA\u548ceGFR\u7684\u53d8\u5316\u60c5\u51b5<\/span><\/p>\n


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GcfDNA\u9884\u6d4b\u79fb\u690d\u672f\u540e\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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David\u7b49\u4eba[4]<\/sup>\u5206\u6790\u4e861296\u4f8b\u60a3\u8005\uff08KOAR\u7814\u7a76\uff09\u672f\u540e100\u5929\u5185\u7684GcfDNA\u68c0\u6d4b\u7ed3\u679c\uff0c\u5e76\u8bc4\u4f30\u4ece\u672f\u540e100\u5929\u5f00\u59cb\u60a3\u8005\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u60c5\u51b5\u3002<\/p>\n


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\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u6d3b\u68c0\u8bc1\u5b9e\u6392\u65a5\u53cd\u5e94\u3001\u51fa\u73b0dnDSA\u53ca\u518d\u6b21\u900f\u6790\u3002\u8be5\u7814\u7a76\u4e2d\u517151\u4f8b\u60a3\u8005\u5728\u672f\u540e100\u5929\u5185\u51fa\u73b0GcfDNA\u22651.0%\uff0c\u8fd9\u4e9b\u60a3\u8005\u672f\u540e1\u5e74\u5185\u53d1\u751f\u590d\u5408\/\u5355\u4e00\u4e0d\u826f\u4e8b\u4ef6\u7684\u98ce\u9669\u5747\u660e\u663e\u5347\u9ad8(\u56fe3)\u3002<\/p>\n<\/section>\n


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\u56fe3\uff1a\u672f\u540e1\u5e74\u5185\u6392\u65a5\u53cd\u5e94\u3001dnDSA\u53ca\u518d\u6b21\u900f\u6790\u7684\u53d1\u751f\u7387\uff08AS\uff0callosure\uff09<\/span>
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\u8be5\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u5728\u7eb3\u5165\u4f9b\u4f53\u7c7b\u578b\u3001\u53d7\u4f53\u5e74\u9f84\u3001\u53d7\u4f53\u81f4\u654f\u60c5\u51b5\u548cDGF\u7684\u591a\u53d8\u91cfCox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b\u4e2d\uff0c\u53ea\u6709\u672f\u540e100\u5929GcfDNA\u5347\u9ad8\u22651.0%\u53ef\u4f5c\u4e3a\u7efc\u5408\u4e0d\u826f\u4e8b\u4ef6\u7684\u9884\u6d4b\u56e0\u5b50\uff0cHR 2.99 (95% CI: 1.59 -5.61, p < 0.005)(\u88681)\u3002<\/p>\n


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\u88681\uff1a\u672f\u540e1\u5e74\u53d1\u751f\u7efc\u5408\u4e0d\u826f\u4e8b\u4ef6\u7684\u5371\u9669\u56e0\u7d20<\/span><\/p>\n


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Bogdan\u7b49\u4eba[5]<\/sup>\u7eb3\u5165\u4e862\u5e74\u5185\u5728\u534e\u76db\u987f\u5927\u5b66\u63a5\u53d7\u4e86GcfDNA\u68c0\u6d4b\u7684\u80be\u79fb\u690d\u60a3\u8005\u5171171\u4f8b\uff0c\u968f\u8bbf\u81f3\u5c1112\u4e2a\u6708\u3002\u5c06GcfDNA\u5347\u9ad8\u5b9a\u4e49\u4e3a\u6c34\u5e73\u22650.5%\u3002<\/p>\n


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\u7ed3\u679c\u63d0\u793a\u4e0eGcfDNA\u672a\u5347\u9ad8\u7684\u60a3\u8005\u76f8\u6bd4\uff0cGcfDNA\u5347\u9ad8\u7684\u60a3\u8005eGFR\u4e0b\u964d\u66f4\u5feb\uff08\u6bcf\u6708eGFR\u7edd\u5bf9\u503c\u4e0b\u964d\uff1a0.21 vs -0.03 ml\/min\uff0cGFR\u4e0b\u964d\u767e\u5206\u6bd48.7% vs -1.14%\uff0cp=0.09)(\u56fe4)\u3002<\/p>\n


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\u6b64\u5916\uff0c\u4e0eDSA\u9634\u6027\u6216\u9633\u6027\u4e14GcfDNA\u6b63\u5e38\u7684\u60a3\u8005\u76f8\u6bd4\uff0cDSA\u9633\u6027\u4f34GcfDNA\u5347\u9ad8\u7684\u60a3\u8005eGFR\u4e0b\u964d\u767e\u5206\u6bd4\u66f4\u5927\u3002\u5728\u591a\u53d8\u91cflogistic\u56de\u5f52\u5206\u6790\u4e2d\uff0cGcfDNA\u6c34\u5e73\u5347\u9ad8\u4e0eeGFR\u767e\u5206\u6bd4\u4e0b\u964d\u72ec\u7acb\u76f8\u5173(OR0.96\uff0c95%CI 0.93-1.00\uff0cp = 0.05)\u3002<\/p>\n<\/section>\n


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\u56fe4\uff1a\u4e0d\u540cGcfDNA\u6c34\u5e73\u7ec4\u95f4\u60a3\u8005eGFR\u7684\u4e0b\u964d\u60c5\u51b5<\/span>
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Summary<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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GcfDNA\u5bf9\u4e8e\u9884\u6d4b\u6025\u6027\u6392\u65a5\u53cd\u5e94\u3001\u672f\u540e\u80be\u529f\u80fd\u53d8\u5316\u53ca\u8bc4\u4f30\u6392\u65a5\u53cd\u5e94\u6cbb\u7597\u7597\u6548\u5747\u5177\u6709\u4e00\u5b9a\u4ef7\u503c\uff0c\u672f\u540e\u5b9a\u671f\u968f\u8bbfGcfDNA\u5c06\u4f7f\u80be\u79fb\u690d\u60a3\u8005\u4e34\u5e8a\u83b7\u76ca\u3002<\/span>
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Reference:<\/span><\/p>\n

1.Evangelos Mantios, et al. Assessment of donor derived cell free DNA (ddcfDNA) at surveillance and at clinical suspicion of acute rejection in renal transplantation. 2022<\/p>\n

2.Alejandra Mena-Gutierrez, et al. Donor-derived cell-free DNA testing in kidney transplantation: do one-month values have any prognostic significance? 2022<\/p>\n

3.Reginald Gohh, et al. Donor-derived cell-free DNA (dd-cfDNA) for assessment of response after treatment of allograft rejection. 2022<\/p>\n

4.David Wojciechowski, et al. Elevated donor-derived cell-free DNA (dd-cfDNA) in the early post-transplant period is associated with an increased incidence of adverse clinical outcomes in kidney transplant recipients. 2022<\/p>\n

5.Bogdan Obrisca, et al. Elevated donor-derived cell-free DNA associates with subsequent decline of allograft function. 2022<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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