{"id":1176,"date":"2023-04-21T17:00:37","date_gmt":"2023-04-21T09:00:37","guid":{"rendered":"https:\/\/www.transnovo.com\/?p=1176"},"modified":"2023-04-21T17:00:37","modified_gmt":"2023-04-21T09:00:37","slug":"%e9%9c%89%e9%85%9a%e9%85%b8%e7%b1%bb%e8%8d%af%e7%89%a9%e8%8d%af%e4%bb%a3%e5%8a%a8%e5%8a%9b%e5%ad%a6%e4%b8%aa%e4%bd%93%e5%8c%96%e5%b7%ae%e5%bc%82%e5%92%8ctdm%e7%9b%91%e6%b5%8b","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/%e9%9c%89%e9%85%9a%e9%85%b8%e7%b1%bb%e8%8d%af%e7%89%a9%e8%8d%af%e4%bb%a3%e5%8a%a8%e5%8a%9b%e5%ad%a6%e4%b8%aa%e4%bd%93%e5%8c%96%e5%b7%ae%e5%bc%82%e5%92%8ctdm%e7%9b%91%e6%b5%8b\/","title":{"rendered":"\u9709\u915a\u9178\u7c7b\u836f\u7269\u836f\u4ee3\u52a8\u529b\u5b66\u4e2a\u4f53\u5316\u5dee\u5f02\u548cTDM\u76d1\u6d4b"},"content":{"rendered":"
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\u4e0d\u540c\u5242\u578b\u9709\u915a\u9178\u7c7b\u836f\u7269<\/strong><\/p>\n

\u836f\u4ee3\u52a8\u529b\u5b66\u4e2a\u4f53\u5316\u5dee\u5f02<\/strong><\/p>\n

\u00a0 \u00a0 \u4e0e\u5417\u66ff\u9ea6\u8003\u915a\u916f\uff08MMF\uff09\u76f8\u6bd4\uff0c\u9ea6\u8003\u915a\u94a0\u80a0\u6eb6\u7247\uff08EC-MPS\uff09\u836f\u4ee3\u52a8\u529b\u5b66\u5728\u4e2a\u4f53\u95f4\u548c\u4e2a\u4f53\u5185\u53d8\u5f02\u66f4\u9ad8\uff0c\u4e14\u8fd9\u79cd\u5dee\u5f02\u5e76\u4e0d\u968f\u7740\u79fb\u690d\u540e\u65f6\u95f4\u7684\u63a8\u79fb\u5f97\u5230\u6539\u5584\u3002\u8fd9\u79cd\u5dee\u5f02\u5728\u8f6c\u6362\u4e3aMMF\u540e\u53ef\u5f97\u5230\u660e\u663e\u6539\u55842,3\u3002\u7f57\u9a6c\u5171\u8bc6\u6307\u51faEC-MPS\u4e2a\u4f53\u5dee\u5f02\u53d8\u5316\u66f4\u5927\uff0cMMF\u548cEC-MPS\u4e0d\u5b58\u5728\u771f\u6b63\u7684\u201c\u751f\u7269\u7b49\u6548\u6027\u201d4\u3002<\/p>\n

# \u80be\u79fb\u690d\u540e6\u300124\u548c30\u4e2a\u6708\uff0c<\/strong><\/p>\n

MMF\u548cEC-MPS\u6cbb\u7597\u7684\u6d53\u5ea6\u65f6\u95f4\u66f2\u7ebf #<\/strong><\/p>\n

<\/strong><\/p>\n

\u4e00\u9879\u4e0d\u540c\u5242\u578b\u9709\u915a\u9178\u7c7b\u836f\u7269\u5728\u65e9\u671f\u80be\u79fb\u690d\u60a3\u8005\u4f53\u5185\u7684\u836f\u52a8\u5b66\u7814\u7a76\uff0c\u7eb3\u5165121\u4f8b\u80be\u79fb\u690d\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\u60a3\u8005\u4e2a\u4f53\u95f4MPA\u7684\u836f\u52a8\u5b66\u5dee\u5f02\u8f83\u5927\uff0cMMF\u7ec4\uff08\u5417\u66ff\u9ea6\u8003\u915a\u916f\u80f6\u56ca\u7ec4\uff09\u3001MMF-T\u7ec4\uff08\u5417\u66ff\u9ea6\u8003\u915a\u916f\u5206\u6563\u7247A\uff09\u3001MMF-DT\u7ec4\uff08\u5417\u66ff\u9ea6\u8003\u915a\u916f\u5206\u6563\u7247B\uff09\u548cEC-MPS\u7ec4\u4e2d\uff0cEC-MPS\u7ec4\u5728\u4e2a\u4f53\u95f4\u548c\u4e2a\u4f53\u5185\u53d8\u5f02\u6700\u9ad85\u3002<\/p>\n

# \u80be\u79fb\u690d\u60a3\u8005\u53e3\u670d\u5417\u66ff\u9ea6\u8003\u915a\u916f\u80f6\u56ca\u540e\u7684<\/strong><\/p>\n

\u8840\u6d46MPA\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf #<\/strong><\/p>\n

<\/strong><\/p>\n

\n

# \u80be\u79fb\u690d\u60a3\u8005\u53e3\u670d\u5417\u66ff\u9ea6\u8003\u915a\u916f\u5206\u6563\u7247A\u540e<\/strong><\/p>\n

\u7684\u8840\u6d46MPA\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf #<\/strong><\/p>\n

<\/strong><\/p>\n

# \u80be\u79fb\u690d\u60a3\u8005\u53e3\u670d\u5417\u66ff\u9ea6\u8003\u915a\u916f\u5206\u6563\u7247B<\/strong><\/p>\n

\u540e\u7684\u8840\u6d46MPA\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf #<\/strong><\/p>\n

<\/strong><\/p>\n

# \u80be\u79fb\u690d\u60a3\u8005\u53e3\u670d\u9ea6\u8003\u915a\u94a0\u80a0\u6eb6\u7247\u540e<\/strong><\/p>\n

\u7684\u8840\u6d46MPA\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf #<\/strong><\/p>\n

<\/strong><\/p>\n

\u9709\u915a\u9178\u7c7b\u884d\u751f\u7269\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b<\/strong><\/p>\n

\n

\u00a0 \u00a0 \u00a02019\u7248\u4e2d\u56fd\u5668\u5b98\u79fb\u690d\u514d\u75ab\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\u6280\u672f\u89c4\u8303\u6307\u51fa\uff0cMPA\u7c7b\u836f\u7269\u5305\u62ecMMF\u548cEC-MPS\u3002\u4e24\u8005\u8fdb\u5165\u4f53\u5185\u540e\uff0c\u867d\u5438\u6536\u65f6\u95f4\u53ca\u6548\u7387\u4e0d\u540c\uff0c\u5728\u4f53\u5185\u7684\u6709\u6548\u6210\u5206\u5747\u662fMPA\u3002MPA\u5728\u4eba\u4f53\u5185\u836f\u4ee3\u52a8\u529b\u5b66\u4e2a\u4f53\u5dee\u5f02\u5927\uff0c\u5bf9\u670d\u7528MPA\u7684\u79fb\u690d\u53d7\u8005\u8fdb\u884c\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b\uff0c\u53ef\u9632\u6b62\u6216\u51cf\u5c11\u836f\u7269\u7684\u6bd2\u6027\u53ca\u4e0d\u826f\u53cd\u5e94\uff0c\u5ef6\u957f\u79fb\u690d\u7269\u5b58\u6d3b\u671f\u300298%\u7684MPA\u4e0e\u8840\u6d46\u86cb\u767d\u7ed3\u5408\uff0c\u9001\u68c0\u6837\u672c\u6700\u597d\u662fEDTA\u6297\u51dd\u7ba1\u5168\u8840\u3002MMF\u7684\u76d1\u6d4b\u65f6\u95f4\u4e3a\u6b21\u65e5\u6e05\u6668\u670d\u836f\u524d30min\uff08C0\u8c37\u503c\uff09\u3001\u670d\u836f\u540e0.5h\uff08C0.5\uff09\u53ca\u670d\u836f\u540e2h\uff08C2\uff09\uff1bEC-MPS\u7684\u76d1\u6d4b\u65f6\u95f4\u6839\u636e\u8054\u5408\u670d\u7528\u9499\u8c03\u78f7\u9178\u9176\u6291\u5236\u5242\uff08CNI\uff09\u7684\u4e0d\u540c\u800c\u5f026\u3002<\/p>\n

2021\u5e74\u4e2d\u56fd\u4e00\u9879\u7efc\u5408\u5206\u6790\u7eb3\u5165115\u7bc7\u7814\u7a76\uff0c\u51718502\u4f8b\u60a3\u8005\u3002\u7ed3\u679c\u56fd\u5185\u5173\u4e8eMPA\u836f\u7269\u6d53\u5ea6\u76d1\u6d4b\u7684\u7ed9\u836f\u5242\u91cf\u65b9\u6848\u3001\u68c0\u6d4b\u7269\u8d28\u3001\u91c7\u6837\u70b9\u7b49\u8d8b\u4e8e\u4e00\u81f4\uff0c\u4f46\u5173\u4e8e\u4e0d\u540c\u5c42\u6b21\u7684\u60a3\u8005\u4eba\u7fa4\u3001\u7ed9\u836f\u5242\u578b\u3001\u8054\u5408\u7528\u836f\u53ca\u76d1\u6d4b\u65b9\u6cd5\u6bd4\u8f83\u7b49\u7814\u7a76\u8f83\u5c11\u3002\u76ee\u524d\uff0c\u4e34\u5e8a\u5e38\u91c7\u7528HPLC\u6cd5\u6216EMIT\u6cd5\u76d1\u6d4bMPA\u6d53\u5ea6\uff0c\u4f46\u5173\u4e8e\u4e8c\u8005\u7684\u6bd4\u8f83\u5c1a\u65e0\u7edf\u4e00\u6807\u51c6\u3002\u6709\u7814\u7a76\u8bc1\u5b9e\uff0cfMPA\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u7684\u6d53\u5ea6\u4e0e\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u5177\u6709\u4e00\u5b9a\u7684\u76f8\u5173\u6027\uff0c\u4f46\u5c1a\u65e0\u53ef\u53c2\u8003\u7684\u6d53\u5ea6\u8303\u56f4\u3002\u6d4b\u91cfAUC\u88ab\u89c6\u4f5c\u76d1\u6d4b\u836f\u7269\u6d53\u5ea6\u7684\u91d1\u6807\u51c6\uff0c\u4f46\u4e34\u5e8a\u53ef\u884c\u6027\u53ca\u60a3\u8005\u63a5\u53d7\u5ea6\u8f83\u5dee\u3002\u76ee\u524d\u591a\u6570\u7814\u7a76\u91c7\u7528\u6709\u9650\u91c7\u6837\u70b9(LSS)\u516c\u5f0f\uff0c\u62df\u5408\u51fa\u6700\u4f73\u91c7\u6837\u70b9\uff0c\u4f46\u7531\u4e8e\u7814\u7a76\u4eba\u7fa4\u53ca\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u5b58\u5728\u5dee\u5f02\u7b49\u539f\u56e0\uff0c\u76ee\u524d\u5c1a\u65e0LSS\u516c\u5f0f\u5f97\u5230\u5e7f\u6cdb\u5916\u63a87\u3002<\/p>\n

 <\/p>\n

Summary<\/strong><\/p>\n

\u00a0 \u00a0MMF\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4e2a\u4f53\u5316\u5dee\u5f02\u6bd4EC-MPS\u66f4\u5c0f\uff0c\u7a33\u5b9a\u6027\u66f4\u9ad8\uff0c\u76d1\u6d4b\u66f4\u65b9\u4fbf\u3002MMF\u7684\u76d1\u6d4b\u65f6\u95f4\u4e3a\u6b21\u65e5\u6e05\u6668\u670d\u836f\u524d30min\u3001\u670d\u836f\u540e0.5h\u53ca\u670d\u836f\u540e2h\uff0c\u4e34\u5e8a\u5e38\u91c7\u7528HPLC\u6cd5\u6216EMIT\u6cd5\u76d1\u6d4bMPA\u6d53\u5ea6\uff1bEC-MPS\u7684\u76d1\u6d4b\u65f6\u95f4\u9700\u6839\u636e\u8054\u5408\u670d\u7528CNI\u7684\u4e0d\u540c\u800c\u5f02\u3002<\/p>\n

 <\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/strong><\/p>\n

1.\u66f9\u61ff\u777f,\u8d3e\u4ea6\u81e3.\u9709\u915a\u9178\u7c7b\u836f\u7269\u5728\u5668\u5b98\u79fb\u690d\u53d7\u8005\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u8fdb\u5c55.\u5668\u5b98\u79fb\u690d. 2020,11(5):635-645.<\/p>\n

2. Tett SE, et al. Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure. Transplant Rev (Orlando). 2011;25(2):47\u201357.<\/p>\n

3. Meur Y L , et al. Therapeutic drug monitoring of mycophenolates in kidney transplantation: report of The Transplantation Society consensus meeting. Transplantation Reviews, 2011, 25(2):58-64.<\/p>\n

4.Cattaneo D, et al. Pharmacokinetics of mycophenolate sodium and comparison with the mofetil formulation in stable kidney transplant recipients. Clin J Am Soc Nephrol. 2007 Nov;2(6):1147-55.<\/p>\n

5.\u5f20\u7eee\u96ef,\u7b49. \u4e0d\u540c\u5242\u578b\u9709\u915a\u9178\u7c7b\u836f\u7269\u5728\u65e9\u671f\u80be\u79fb\u690d\u60a3\u8005\u4f53\u5185\u7684\u836f\u52a8\u5b66\u7814\u7a76\u53ca\u4e0d\u826f\u53cd\u5e94\u5206\u6790. \u4e2d\u56fd\u836f\u5b66\u6742\u5fd7, 55(17):1461-1469.<\/p>\n

6.\u5668\u5b98\u79fb\u690d\u514d\u75ab\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\u6280\u672f\u89c4\u8303(2019\u7248). \u5668\u5b98\u79fb\u690d, 2019, 10(3):213-226.<\/p>\n

7.\u5218\u723d,\u7b49.\u4e2d\u56fd\u9709\u915a\u9178\u6cbb\u7597\u836f\u7269\u76d1\u6d4b\u7684\u73b0\u72b6\u5206\u6790. \u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u6742\u5fd7 2021,37(3): 308-311<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

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