{"id":1146,"date":"2023-04-21T16:44:04","date_gmt":"2023-04-21T08:44:04","guid":{"rendered":"https:\/\/www.transnovo.com\/?p=1146"},"modified":"2023-04-21T16:45:17","modified_gmt":"2023-04-21T08:45:17","slug":"gcfdna-%e9%a2%84%e6%b5%8b%e5%92%8c%e9%89%b4%e5%88%ab%e8%82%9d%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e7%9a%84%e6%96%b0%e5%9e%8b%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9","status":"publish","type":"post","link":"https:\/\/transnovo.com\/en\/news\/gcfdna-%e9%a2%84%e6%b5%8b%e5%92%8c%e9%89%b4%e5%88%ab%e8%82%9d%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e7%9a%84%e6%96%b0%e5%9e%8b%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9\/","title":{"rendered":"GcfDNA - a novel biomarker for the prediction and identification of liver rejection"},"content":{"rendered":"<div class=\"content\">\n<div>\n<section>\n<section>\n<section>\n<section>\n<p style=\"text-align: center;\"><strong>Preface<\/strong><\/p>\n<p style=\"text-align: center;\">\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<p style=\"text-align: center;\">\u6211\u56fd\u5668\u5b98\u6350\u732e\u4e0e\u79fb\u690d\u6570\u91cf\u5df2\u4f4d\u5c45\u5168\u7403\u7b2c\u4e8c\uff0c\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u662f\u672f\u540e\u5e38\u89c1\u7684\u5e76\u53d1\u75c7\u3002\u5c3d\u7ba1\u6709\u6709\u6548\u7684\u514d\u75ab\u6291\u5236\u836f\u7684\u4f7f\u7528\uff0c\u4f46\u8fd8\u662f\u9ad8\u8fbe1\/3\u7684\u809d\u79fb\u690d\u53d7\u8005 (LTR) \u4f1a\u51fa\u73b0\u6025\u6027\u6392\u65a5\u53cd\u5e94<sup>1<\/sup>.<\/p>\n<p style=\"text-align: center;\">\u6240\u4ee5\u5728\u809d\u79fb\u690d(LT)\u540e\u7684\u5934\u51e0\u4e2a\u6708\u90fd\u9700\u8981\u76d1\u6d4b\u79fb\u690d\u7269\u7684\u809d\u529f\u80fd\uff0c\u5305\u62ec\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176 (ALT)\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176 (AST)\u3001\u78b1\u6027\u78f7\u9178\u9176 (ALP)\u3001\u03b3-\u8c37\u6c28\u9170\u8f6c\u80bd\u9176 (GGT) \u548c\u80c6\u7ea2\u7d20 (BIL)\uff0c\u7528\u6765\u53d1\u73b0\u6f5c\u5728\u7684\u79fb\u690d\u7269\u635f\u4f24\uff0c<strong>\u4f46\u76ee\u524d\u7684\u809d\u529f\u80fd\u6d4b\u8bd5(LFTs)\u7f3a\u4e4f\u7279\u5f02\u6027\u548c\u654f\u611f\u6027\u3002<\/strong><\/p>\n<p style=\"text-align: center;\">\u867d\u7136\u6d3b\u68c0\u88ab\u8ba4\u4e3a\u662f\u8bca\u65ad\u7684\u201c\u91d1\u6807\u51c6\u201d\uff0c\u4f46\u5176\u8d39\u7528\u9ad8\u3001\u6709\u521b\u4f24\u6027\u4e14\u4f34\u6709\u5e76\u53d1\u75c7\u3001\u53ef\u91cd\u590d\u6027\u5dee\u7b49\u7f3a\u70b9\u9650\u5236\u4e86\u5176\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528\u3002\u56e0\u6b64\uff0c<strong>\u9700\u8981\u4e00\u79cd\u66f4\u5b89\u5168\u3001\u66f4\u51c6\u786e\u7684\u751f\u7269\u6807\u5fd7\u7269\u6765\u76d1\u6d4b\u79fb\u690d\u7269\u529f\u80fd<\/strong>\uff0c\u4ee5\u4fbf\u53ef\u4ee5\u76d1\u6d4b\u65e9\u671f\u7684\u79fb\u690d\u7269\u635f\u4f24\u6216\u6392\u65a5\u72b6\u6001\uff0c\u5e76\u63d0\u4f9b\u53ca\u65f6\u7684\u5e72\u9884\uff0c\u505a\u5230\u65e9\u53d1\u73b0\uff0c\u65e9\u8bca\u65ad\uff0c\u65e9\u6cbb\u7597\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong>\u79fb\u690d\u7269\uff08\u4f9b\u4f53\uff09\u6765\u6e90\u7684\u6e38\u79bbDNA<\/strong>\uff08GcfDNA\uff09\u662f\u5668\u5b98\u79fb\u690d\u672f\u540e\u53d7\u8005\u5faa\u73af\u4f53\u6db2\u4e2d\u6765\u81ea\u4e8e\u51cb\u4ea1\u6216\u574f\u6b7b\u4f9b\u4f53\u7ec6\u80de\u7684\u6e38\u79bbDNA\uff0c\u53ef\u4ee5\u65e9\u671f\u9884\u6d4b\u6392\u65a5\u53cd\u5e94\uff0c\u4e14\u9274\u522b\u672f\u540e\u6392\u65a5\u53cd\u5e94\u654f\u611f\u5ea6\u548c\u7279\u5f02\u5ea6\u8f83\u9ad8\uff0c\u53ef\u4ee5\u907f\u514d\u4e0d\u5fc5\u8981\u7684\u6d3b\u68c0\uff0c\u662f\u79fb\u690d\u672f\u540e\u9884\u6d4b\u53ca\u9274\u522b\u6392\u65a5\u53cd\u5e94\u8f83\u597d\u7684\u65b0\u578b\u751f\u7269\u6807\u5fd7\u7269<sup>2<\/sup>.<\/p>\n<\/section>\n<p style=\"text-align: center;\">\u8fd1\u5e74\u6765\uff0c\u5173\u4e8eGcfDNA\u5728\u809d\u810f\u79fb\u690d\u672f\u540e\u9884\u6d4b\u53ca\u9274\u522b\u672f\u540e\u6392\u65a5\u53cd\u5e94\u7684\u5faa\u8bc1\u8bc1\u636e\u8f83\u591a\u3002<\/p>\n<p style=\"text-align: center;\">Ekkehard\u7684\u4e00\u9879\u524d\u77bb\u6027\u591a\u4e2d\u5fc3\u7684\u89c2\u5bdf\u6027\u7814\u7a76\uff0c\u5bf9115\u4f8b\u6210\u5e74\u60a3\u8005\u8fdb\u884c\u809d\u529f\u80fd\u68c0\u6d4b\uff08LFTs\uff09\u548cGcfDNA\u68c0\u6d4b\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u7ecf\u6d3b\u68c0\u8bc1\u5b9e\u7684\u6025\u6027\u6392\u65a5\u7ec4\u4e2d\u7684GcfDNA\u4e2d\u4f4d\u503c\u663e\u8457\u9ad8\u4e8e\u7a33\u5b9a\u7ec4\uff0829.6% vs 3.3%;P &lt; 0.001\uff0c\u56fe1\uff09\uff0c\u5728HCV+\u7684\u65e0\u6392\u65a5\u53cd\u5e94\u60a3\u8005\u7ec4\u4e2dGcfDNA\u4e2d\u4f4d\u503c\u7565\u5347\u9ad8\uff085.9%\uff09\uff0cLFTs\u4e0eGcfDNA\u68c0\u6d4b\u603b\u4f53\u76f8\u5173\u6027\u8f83\u4f4e\uff08r = 0.28~0.62\uff09\u3002<\/p>\n<p style=\"text-align: center;\">\u591a\u53d8\u91cf\u903b\u8f91\u56de\u5f52\u6a21\u578b\u663e\u793a\uff0c<strong>GcfDNA\u53ef\u7528\u4e8e\u9274\u522b\u6025\u6027\u6392\u65a5\u53cd\u5e94\uff0c\u9608\u503c\u4e3a10%\u65f6\uff0cGcfDNA\u7684\u9274\u522b\u654f\u611f\u5ea6\u548c\u7279\u5f02\u5ea6\u9ad8\u8fbe90.3%\u548c92.9%\uff0cAUC\u8fbe\u523096.5%<\/strong>\uff08\u56fe2\uff09<sup>3<\/sup>.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" src=\"https:\/\/img.gejiba.com\/image\/G5OK1\" alt=\"\" \/><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/img.gejiba.com\/images\/0a74ffa71566460a7a42b5f8994bc66e.png\" alt=\"\" width=\"487\" height=\"349\" \/>\u56fe1.\u4e0d\u540c\u7c7b\u578b\u60a3\u8005GcfDNA\u6c34\u5e73\u6bd4\u8f83<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/img.gejiba.com\/images\/55f19432335cd023fbca3b033de1838c.png\" alt=\"\" width=\"548\" height=\"524\" \/><\/p>\n<section>\n<p style=\"text-align: center;\">\u56fe2.\u7ecf\u6d3b\u68c0\u8bc1\u5b9e\u7684AR\u60a3\u8005GcfDNA\u66f2\u7ebf<\/p>\n<\/section>\n<section>\u00a0<\/section>\n<section>\n<p style=\"text-align: center;\">2022\u5e74\u53d1\u8868\u76842\u7bc7\u809d\u79fb\u690d\u7814\u7a76\uff0c\u4e00\u7bc7\u7814\u7a76\u7eb3\u5165\u4e4b\u524d\u5355\u4e2d\u5fc3\u548c\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5c06\u7ecf\u6d3b\u68c0\u8bc1\u5b9e\u7684\u6025\u6027\u6392\u65a5\u53cd\u5e94\uff08AR\uff09\u3001\u529f\u80fd\u6b63\u5e38(TX)\u548c\u6025\u6027\u529f\u80fd\u969c\u788d\u65e0\u6392\u65a5\u53cd\u5e94(ADNR)\u5206\u4e3a\u8bad\u7ec3\u7ec4\u548c\u6d4b\u8bd5\u7ec4\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u5728\u8bad\u7ec3\u7ec4\u4e2d\uff0cGcfDNA\u5728AR\u4e0eTX\u548cAR\u4e0eADNR\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff08\u56fe3\uff09\u3002<\/strong><strong>\u8fde\u7eed\u91c7\u96c6\u8840\u6837\u663e\u793a\uff0c\u5728\u79fb\u690d\u7269\u529f\u80fd\u969c\u788d\u53d1\u751f\u524d\uff0cGcfDNA\u5448\u589e\u91cf\u5347\u9ad8\uff0c\u4f46\u5728TX\u7ec4\u4e2d\u5e76\u975e\u5982\u6b64\u3002<\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56e0\u6b64\uff0cGcfDNA\u6709\u52a9\u4e8e\u65e9\u671f\u53d1\u73b0\u79fb\u690d\u6392\u65a5\u53cd\u5e94<sup>1<\/sup>.<\/strong><\/p>\n<p><strong><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/img.gejiba.com\/images\/6c9a04e00b39da8be48d155b0f02b60f.png\" alt=\"\" width=\"577\" height=\"549\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe3. GcfDNA\u9274\u522b\u6392\u65a5\u53cd\u5e94<\/strong><\/p>\n<p><strong><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/img.gejiba.com\/images\/4f5f0e99e7b4ce098d39b38ec67b11de.png\" alt=\"\" width=\"593\" height=\"430\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe4. GcfDNA\u767e\u5206\u6bd4\u4f5c\u4e3a AR \u7684\u9884\u540e\u6216\u8bca\u65ad\u4f5c\u7528<\/strong><\/p>\n<section>\n<p style=\"text-align: center;\">\u53e6\u4e00\u7bc7\u7814\u7a76\u5bf920\u4f8b\u65e0\u6392\u65a5\u53cd\u5e94\u548c7\u4f8bT\u7ec6\u80de\u4ecb\u5bfc\u7684AR\u60a3\u8005\uff0c\u5728\u809d\u79fb\u690d\u672f\u540e3\u4e2a\u6708\u5185\u68c0\u6d4bGcfDNA\uff0c\u7ed3\u679c\u663e\u793a\uff0cGcfDNA\u5728AR\u8bca\u65ad\u524d\u5347\u9ad83\u500d\uff0834.8%\uff0cP &lt; 0.001\uff09\uff0c\u5728AR\u786e\u8bca\u7ec4\u4e5f\u663e\u8457\u9ad8\u4e8e\u65e0\u6392\u65a5\u53cd\u5e94\u5e94\u8005\u7ec4\uff0823.8% vs 10.6%\uff0cP = 0.05\uff09\uff0c\u4e0e\u4f20\u7edfLFTs\u76f8\u6bd4\uff0c\u5728\u9884\u6d4b\u672f\u540e\u524d\u4e24\u5468\u5185\u6392\u65a5\u53cd\u5e94\u65b9\u9762\u8868\u73b0\u51fa\u66f4\u597d\u7684\u9884\u6d4b\u6548\u679c(AUC = 84.6%)\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u7814\u7a76\u8868\u660e\uff0cGcfDNA\u53ef\u4f5c\u4e3a\u9884\u6d4b\u6392\u65a5\u53cd\u5e94\u7684\u751f\u7269\u6807<\/strong><strong>\u5fd7\u7269\uff08\u56fe4\uff09<sup>4<\/sup>.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<p style=\"text-align: center;\">\u00a0 \u00a0<strong>Summary<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<p style=\"text-align: center;\">GcfDNA\u4f5c\u4e3a\u65b0\u578b\u7684\u65e0\u521b\u6027\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5728\u6392\u65a5\u53cd\u5e94\u60a3\u8005\u4e2d\u65e9\u671f\u4f1a\u51fa\u73b0\u663e\u8457\u5347\u9ad8\uff0c\u4e14\u9274\u522b\u654f\u611f\u5ea6\u548c\u7279\u5f02\u5ea6\u9ad8\u8fbe90.3%\u548c92.9%<sup>3<\/sup>\uff0c\u53ef\u7528\u4e8e\u65e9\u671f\u9884\u6d4b\u53ca\u9274\u522b\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u76ee\u524d\u6211\u53f8\u5065\u8015\u533b\u836f\u4e5f\u5f00\u5c55\u4e86GcfDNA\u52a8\u6001\u76d1\u6d4b\u9879\u76ee\uff0c\u6709\u5174\u8da3\u7684\u4e13\u5bb6\u6b22\u8fce\u7559\u8a00\u6216\u8005\u8054\u7cfb\u6211\u4eec\u56e2\u961f\uff0c\u6211\u4eec\u4f1a\u53ca\u65f6\u56de\u590d\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<section>\n<section>\n<section>\n<p style=\"text-align: left;\">Reference:<\/p>\n<p style=\"text-align: center;\">1. Levitsky J, et al. Donor-Derived Cell-Free DNA Levels Predict Graft Injury in Liver Transplant Recipients. Am J Transplant. 2022;22(2):532-540.<\/p>\n<p style=\"text-align: center;\">2. Oellerich M, et al. Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury. Nat Rev Nephrol . 2021;17(9):591-603.<\/p>\n<p style=\"text-align: center;\">3. Sch\u00fctz E, et al. Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study. PLoS Med. 2017;14(4):e1002286.<\/p>\n<p style=\"text-align: center;\">4.Fern\u00e1ndez-Gal\u00e1n E, et al. Monitoring of ddcfDNA by STRs, concentration of total cfDNA and fragment size foracute rejection risk assessment in liver transplantation. Liver Transpl. 2022;28(2):257-268.<\/p>\n<\/section>\n<\/section>\n<section>\n<p style=\"text-align: center;\">\n<\/section>\n<\/section>\n<\/div>\n<\/div>\n<div id=\"gtx-trans\" style=\"position: absolute; left: -38px; top: 3502.07px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u524d\u8a00 \u6211\u56fd\u5668\u5b98\u6350\u732e\u4e0e\u79fb\u690d\u6570\u91cf\u5df2\u4f4d\u5c45\u5168\u7403\u7b2c\u4e8c\uff0c\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u662f\u672f\u540e\u5e38\u89c1\u7684\u5e76\u53d1\u75c7\u3002\u5c3d\u7ba1\u6709\u6709\u6548\u7684\u514d\u75ab\u6291\u5236\u836f\u7684\u4f7f\u7528\uff0c\u4f46\u8fd8 [&hellip;]<\/p>","protected":false},"author":6,"featured_media":1147,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>GcfDNA\u2014\u2014\u9884\u6d4b\u548c\u9274\u522b\u809d\u6392\u65a5\u53cd\u5e94\u7684\u65b0\u578b\u751f\u7269\u6807\u5fd7\u7269 - 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